Results 131 to 140 of about 2,451,925 (307)

How to Build a Wind Turbine: Introducing Fourth Graders to Engineering in KidWind Project [PDF]

, 2019
With colored construction paper, Styrofoam cups, coffee filters, cereal boxes, empty toilet paper rolls, and straws splayed across the desks, Mrs. McCanna’s fourth grade classroom filled with excited chatter as her students constructed small-scale wind ...
Dell\u27Agnese, Courtney
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

List of contents and message from the Responsible Director [PDF]

Journal of Structural and Construction Engineering, 2016
Message from the Responsible Director     I am glad to announce publication of Volume 3, No.2 (2016) of Journal of “Structural and Construction Engineering”.
GholamReza Havaei
doaj  

Delivery status of the ELI-NP gamma beam system [PDF]

, 2016
International audienceThe ELI-NP GBS is a high intensity and monochromatic gamma source under construction in Magurele (Romania). The design and construction of the Gamma Beam System complex as well as the integration of the technical plants and the ...
Alesini, D., Bacci, A., Battisti, A., Bliss, N., Boni, R., Cardelli, Fabio, Cassou, K., Cioeta, F., D'Auria, G., Delle Piane, A., Di Pasquale, E., Di Pirro, G., Falone, A., Gallo, A., Giribono, Anna, Hill, C., Incremona, S., Lollo, V., Mostacci, Andrea, Palmer, D., Palumbo, Luigi, Pettinacci, V., Piersanti, Luca, Pioli, Stefano, Ricci, R., Rotundo, U., Serafini, L., Stella, A., Tomassini, S., Vaccarezza, C., Vannozzi, Alessandro, Variola, A., Zomer, F.   +32 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Industry-driven innovative system development for the construction industry: The DIVERCITY project [PDF]

, 2004
Collaborative working has become possible using the innovative integrated systems in construction as many activities are performed globally with stakeholders situated in various locations.
Aouad, GF, Arayici, Y
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

RWU Approves Campus Location for New SECCM Labs [PDF]

, 2017
With Trustees\u27 approval, RWU plans to break ground in spring on School of Engineering, Computing and Construction Management ...
Fitzpatrick, Edward
core   +1 more source