An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
BuildingsThe trend of global warming remains severe. As one of the major sources of carbon emissions, the construction industry still requires large-scale and effective transformations.
Yuan Mei, Haokun Wang, Dongbo Zhou
doaj +1 more source
PMO Conceptualization for Engineering and Construction Businesses
Procedia Computer Science, 2017 Over the last decade many organizations began to recognize that the implementation of Project Management (PM) practices was a necessity rather than an option. In order to improve the success of projects, organizations have been adopting specialized structures (normally called PM Offices or PMOs) that carry out the management of projects in a ...
Catarina Oliveira +2 more
openaire +2 more sources
Mega-city construction engineering to residential satisfaction: new insights from Yan' an of China. [PDF]
Front Public Health, 2023 Huang H, Qian XM, Xiao Y, Luo ZX.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Retracted: Comprehensive Evaluation of BIM Calculation Quantity in Domestic Construction Engineering Based on Fuzzy Comprehensive Evaluation. [PDF]
Comput Intell Neurosci, 2023 Intelligence And Neuroscience C.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Global Bibliometric Developments on Solid Waste Recycling in Concrete Construction Engineering. [PDF]
Materials (Basel), 2022 Zhang X +5 more
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Flame-Retardant Mechanisms and Preparation of Polymer Composites and Their Potential Application in Construction Engineering. [PDF]
Polymers (Basel), 2021 Shen J +5 more
europepmc +1 more source