Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A Comparative Analysis of Visualization Methods in Architecture: Employing Virtual Reality to Support the Decision-Making Process in the Architecture, Engineering, and Construction Industry [PDF]
, 2023 Ahmed Redha Gheraba +6 more
openalex +1 more source
Industrialized constructive systems
Informes de la Construccion, 1996 The present article summarizes the main points discussed in three Innovator Buildings Systems sessions, which are about different subjects of Industrialized Building. The first part is about the topic of concrete panels, applied to building flats basically. It is given a historical summary and the general concepts, ending with "INDAGSA BUILDING SYSTEM",
openaire +2 more sources
Identifying higher capability maturity KPAs of construction organisations; Model refinement through expert interviews [PDF]
Process improvement has been identified as a mechanism of achieving the much needed performance improvements within the construction industry. Despite the concerns of being an industry with unique characteristics, construction has borrowed some process ...
Amaratunga, Dilanthi +2 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Implementing efficient and effective learnerships in the construction industry
, 2010 Claudia Mummenthey, Ronel Du Preez
openalex +2 more sources
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Construction Economics and Building, 2010 This is a reprint from Vol 1, no 1, which has not previously been available in electronic format. The analysis and understanding of the conduct and performance of an industry begins with a study of its structure.
Gerard de Valence
doaj +1 more source
Is It a Heavy Log that Broke the Camel’s Back? Evidence of the Credit Channel in Taiwan’s Construction Industry [PDF]
Since the 1997 Asian financial crisis, the monetary authority of Taiwan decreased the interest rate nine times and had every intention to maintain a loose monetary policy.
Chien-An Wang, Chin-Oh Chang
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