Results 111 to 120 of about 314,143 (308)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
BuildingsThis study aims to analyze the perceptions of construction experts in the Chilean construction industry regarding emotional intelligence. This exploratory and qualitative study is based on data collected through semi-structured interviews with ...
Pedro Páez +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Taking forward public procurement reforms in Ghana
, 2006 The construction industry in Ghana, like many others worldwide, has had its fair share of damning independent reviews. Huge and unsustainable foreign debt, excessive budget deficits, huge contractual payment arrears, poor construction performance ...
Male, S +4 more
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FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
Development and Performance Evaluation of a Novel Disc-Buckle Steel Scaffold Joint
BuildingsThe disc-buckle scaffold system demonstrates significant advantages in prefabricated construction applications, particularly in terms of installation efficiency, load-bearing capacity, and standardization.
Si Wei +5 more
doaj +1 more source
Multi-Outcome Construction Policies : Industry-Focused Research Summary
, 2007 The Multi-outcomes Construction Policies research project, funded by the Cooperative\ud Research Centre for Construction Innovation (Project 2006-036-A), sought to explore the\ud costs and benefits of leveraging social outcomes on public construction ...
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Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Responding to the COVID-19 Pandemic in the Construction Industry [PDF]
COVID-19 had a significant impact on the construction industry, whose workers were labeled \u201cessential\u201d and therefore largely remained on the job.
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source