Results 41 to 50 of about 344,688 (293)

Identificatio n Of Key Factors Affecting Waste Management In Life Cycle Of The Construction Project By Using Delphi Technique

Journal of Engineering, 2016
The problem of generated waste as a result of the implementation of construction projects, has been aggravated recently because of construction activity experienced by the world, especially Iraq, which is going through a period of reconstruction, where ...
Identificatio n Of Key Factors Affecting Waste Management In Life Cycle Of The Construction Project By Using Delphi Technique, Sajjad A. M. Al-Kaabi   +1 more
doaj  

Study on Anisotropic Design Method for Pipe Connection Flanges Based on Wire Arc Additive Manufacturing

Journal of Engineering
The structural integrity and manufacturing quality of flanges directly impact the reliability and safety of industrial equipment. However, the existing design criteria are increasingly insufficient to meet the engineering requirements for new flange ...
Xiaoben Chen, Bo Zhang, Fanglin Shen, Chunxiao Jiao, Jingshu Chang, Wangqiang Xiao, Zhiqin Cai, Chuan Feng, Ben Li, Wei Li   +9 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Price Prediction Model of Demand and Supply in the Housing Market [PDF]

MATEC Web of Conferences, 2019
Over recent years, the imbalance between housing demand and supply, particularly in the high-cost housing segment, led to the rapid increase in the house prices.
Zainal Rozlin, Ramli Fazilah, Manap Norpadzlihatun, Ali Maimunah, Kasim Narimah, Noh Hamidun Mohd., Shareh Musa Sharifah Meryam   +6 more
doaj   +1 more source

ADOPTION OF BUILDING INFORMATION MODELING IN THE CONSTRUCTION PROJECT LIFE CYCLE: BENEFITS FOR STAKEHOLDERS

Architecture and Engineering, 2022
Introduction: Building Information Modeling (BIM) is characterized by potential benefits at many phases of the construction project life cycle. However, no comprehensive study has been conducted to evaluate the benefits of BIM adoption and implementation
Nguyen Quoc Toan, Nguyen Van Tam, Tran Ngoc Diep, Pham Xuan Anh   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Experimental and Machine Learning Analysis of High-Strength Concrete Incorporating Waste Slag and Recycled Steel Fiber

Advances in Civil Engineering
The synergistic impact of waste slag and recycled steel fiber on high-strength concrete (HSC) has been needed to produce eco-friendly concrete in recent times.
Maria Binte Mannan, Julia Sultana, Shuvo Dip Datta, Fahim Shahriyar Aditto, Md Mottakin, Md. Habibur Rahman Sobuz, Abu Sayed Mohammad Akid   +6 more
doaj   +1 more source

Analyzing Critical Factors Influencing the Quality Management in Smart Construction Site: A DEMATEL-ISM-MICMAC Based Approach

Buildings
The swift integration of advanced technologies in the construction sector has significantly propelled the adoption of smart construction sites (SCSs).
Shuolin Zhang, Jianzhao Liu, Zirui Li, Xiaer Xiahou, Qiming Li   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source