Results 51 to 60 of about 2,813,060 (306)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The future obligations of "project manager" as construction integral director (DIPE) in the law of buildings construction in spain (LOE) [PDF]

, 2012
In the year 1999 approves the Law of Construction Building (LOE, in Spanish) to regulate a sector such as construction, which contained some shortcomings from the legal point of view.
Rubio Landart, Jaime, Soler Severino, Manuel José   +1 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Price Prediction Model of Demand and Supply in the Housing Market [PDF]

MATEC Web of Conferences, 2019
Over recent years, the imbalance between housing demand and supply, particularly in the high-cost housing segment, led to the rapid increase in the house prices.
Zainal Rozlin, Ramli Fazilah, Manap Norpadzlihatun, Ali Maimunah, Kasim Narimah, Noh Hamidun Mohd., Shareh Musa Sharifah Meryam   +6 more
doaj   +1 more source

Target value design: using collaboration and a lean approach to reduce construction cost [PDF]

, 2012
Target Costing is an effective management technique that has been used in manufacturing for decades to achieve cost predictability during new products development. Adoption of this technique promises benefits for the construction industry as it struggles
Christine Pasquire, Cooper R., Cooper R., Daria Zimina, Ferry D.J., French W.L., Glenn Ballard, Kirkham R.J., Knott T., Lichtig W., Pratt D.J., Reason P., Shewhart W.A.   +12 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Experimental and Machine Learning Analysis of High-Strength Concrete Incorporating Waste Slag and Recycled Steel Fiber

Advances in Civil Engineering
The synergistic impact of waste slag and recycled steel fiber on high-strength concrete (HSC) has been needed to produce eco-friendly concrete in recent times.
Maria Binte Mannan, Julia Sultana, Shuvo Dip Datta, Fahim Shahriyar Aditto, Md Mottakin, Md. Habibur Rahman Sobuz, Abu Sayed Mohammad Akid   +6 more
doaj   +1 more source

Analyzing Critical Factors Influencing the Quality Management in Smart Construction Site: A DEMATEL-ISM-MICMAC Based Approach

Buildings
The swift integration of advanced technologies in the construction sector has significantly propelled the adoption of smart construction sites (SCSs).
Shuolin Zhang, Jianzhao Liu, Zirui Li, Xiaer Xiahou, Qiming Li   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Identificatio n Of Key Factors Affecting Waste Management In Life Cycle Of The Construction Project By Using Delphi Technique

Journal of Engineering, 2016
The problem of generated waste as a result of the implementation of construction projects, has been aggravated recently because of construction activity experienced by the world, especially Iraq, which is going through a period of reconstruction, where ...
Identificatio n Of Key Factors Affecting Waste Management In Life Cycle Of The Construction Project By Using Delphi Technique, Sajjad A. M. Al-Kaabi   +1 more
doaj