Results 41 to 50 of about 231,037 (262)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multi-year maintenance planning framework using multi-attribute utility theory and genetic algorithms

European Transport Research Review, 2020
This paper introduces a comprehensive framework for the development of optimal multi-year maintenance plans for a large number of bridges. A maintenance plan is said to be optimal when, within the given budget, a maximum number of bridges can be ...
Zaharah Allah Bukhsh, Irina Stipanovic, Andre G. Doree   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

PROFILE OF PROJECT MANAGERS’ COMPETENCIES FOR COLLABORATIVE CONSTRUCTION PROJECTS [PDF]

, 2021
Several studies have indicated that project managers’ competencies contribute to construction project success in a considerable manner. However, these studies have mainly addressed subject of the interest in the context of traditional construction ...
Kähkönen, Kalle, Klakegg, Ole Jonny, Aaltonen, Kirsi, Moradi, Sina   +3 more
core  

Risk Management Practices in Ethiopian Somali Regional State Construction Projects

, 2023
Risk management practices are critical for construction companies to prevent any problems caused by uncertainties in the projects. This study examines how risk management is practiced in construction projects of the Somali Regional State in Ethiopia.
Serkan Kivrak, Omar Hiis Udan
core   +1 more source

Study on Groundwater Seepage Characteristics of Urban Interval Tunnels Based on Environmental Factors and Reduction Effects

Advances in Civil Engineering
Mutual interference and different excavation speeds during the construction of twin-tube tunnel have intensified the complexity of groundwater seepage field damage, while the small-interval tunnel has more complex evolution characteristics than ...
Kunping Chen, Zheng Li, Maoyi Liu, Junsheng Du, Ziquan Chen, Hang Zhang   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Collaborative knowledge management—A construction case study [PDF]

, 2009
Due to the new threats and challenges faced by the construction industry today, construction companies must seek new solutions in order to remain ahead of the competition. Knowledge has been identified to be a significant organisational resource, which
Bhargav Dave, Koskela, LJ, Koskela, Lauri, Dave, B, Dave, Bhargav, Lauri Koskela   +5 more
core   +1 more source

Study on Anisotropic Design Method for Pipe Connection Flanges Based on Wire Arc Additive Manufacturing

Journal of Engineering
The structural integrity and manufacturing quality of flanges directly impact the reliability and safety of industrial equipment. However, the existing design criteria are increasingly insufficient to meet the engineering requirements for new flange ...
Xiaoben Chen, Bo Zhang, Fanglin Shen, Chunxiao Jiao, Jingshu Chang, Wangqiang Xiao, Zhiqin Cai, Chuan Feng, Ben Li, Wei Li   +9 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source