Results 41 to 50 of about 11,523,814 (287)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Study on Groundwater Seepage Characteristics of Urban Interval Tunnels Based on Environmental Factors and Reduction Effects

Advances in Civil Engineering
Mutual interference and different excavation speeds during the construction of twin-tube tunnel have intensified the complexity of groundwater seepage field damage, while the small-interval tunnel has more complex evolution characteristics than ...
Kunping Chen, Zheng Li, Maoyi Liu, Junsheng Du, Ziquan Chen, Hang Zhang   +5 more
doaj   +1 more source

Multi-year maintenance planning framework using multi-attribute utility theory and genetic algorithms

European Transport Research Review, 2020
This paper introduces a comprehensive framework for the development of optimal multi-year maintenance plans for a large number of bridges. A maintenance plan is said to be optimal when, within the given budget, a maximum number of bridges can be ...
Zaharah Allah Bukhsh, Irina Stipanovic, Andre G. Doree   +2 more
doaj   +1 more source

RISK MANAGEMENT IN CONSTRUCTION PROJECT MANAGEMENT

Journal of Business Economics and Management, 2006
By adopting risk management, savings potentials can be realized in construction projects. For this reason, for project managers as well as real estate developers, a consideration of the risk management process is worthwhile. The risk management process comprises 6 process steps, which will be discussed in greater detail below. The integration of a risk
openaire   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Study on Anisotropic Design Method for Pipe Connection Flanges Based on Wire Arc Additive Manufacturing

Journal of Engineering
The structural integrity and manufacturing quality of flanges directly impact the reliability and safety of industrial equipment. However, the existing design criteria are increasingly insufficient to meet the engineering requirements for new flange ...
Xiaoben Chen, Bo Zhang, Fanglin Shen, Chunxiao Jiao, Jingshu Chang, Wangqiang Xiao, Zhiqin Cai, Chuan Feng, Ben Li, Wei Li   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Development of a Novel Production Model for Labour Productivity: Modular Construction Toolkit Design

Buildings, 2023
The building industry faces a number of prominent challenges in the coming period. In this article, we focus on productivity in construction, which lags behind other industries despite technological developments.
Mark Geiger, Daniel Hock, Konrad Nübel
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source