Results 71 to 80 of about 12,145,603 (354)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Effect of steel fiber shape and content on printability, microstructure and mechanical properties of 3D printable high strength cementitious materials

Case Studies in Construction Materials
This study investigates the effects of steel fiber shape (straight and hooked-end) and content (0, 0.5, 1.0, and 1.5 vol%) on rheological properties, printability, mechanical performance and microstructure of 3D printable steel fiber reinforced high ...
Zijian Jia, Mengting Zhou, Yu Chen, Wei Wang, Lei Ma, Yuning Chen, Chao Liu, Yamei Zhang   +7 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Integrating continuous mineral-impregnated carbon fibers into digital fabrication with concrete

Materials & Design
Digital concrete technologies, such as 3D concrete printing, have the potential to be game changers in the construction industry by reducing material consumption and offering a high level of automation.
Tobias Neef, Steffen Müller, Viktor Mechtcherine   +2 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use

Materials, 2019
Nanoparticles are defined as ultrafine particles sized between 1 and 100 nanometres in diameter. In recent decades, there has been wide scientific research on the various uses of nanoparticles in construction, electronics, manufacturing, cosmetics, and ...
A. Mohajerani, L. Burnett, John V. Smith, Halenur Kurmus, John Milas, A. Arulrajah, S. Horpibulsuk, A. Abdul Kadir   +7 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Evolution and Current State of Building Materials, Construction Methods, and Building Regulations in the U.K.: Implications for Sustainable Building Practices [PDF]

, 2023
Rune Vagtholm, Amy Matteo, Behrang Vand, Laura Tūpėnaitė   +3 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Air-Entraining Effect on Rheological Properties of Cement-Based Mixtures

Advances in Materials Science and Engineering
The rheological properties and stability of cement-based materials determine the technological properties of concrete mixtures and significantly influence concrete properties.
Aigerim Tolegenova, Gintautas Skripkiunas, Lyudmyla Rishko, Kenzhebek Akmalaiuly   +3 more
doaj   +1 more source