Results 71 to 80 of about 3,082,738 (358)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Low-cost hot-air solar collector [PDF]

open access: yes, 1975
System has only three components per cell. Cell parts are fabricated from readily available materials and, following a construction procedure which requires use of only simple handtools, can be mounted in place by one ...
Anthony, K. G., Herndon, E. P.
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Air-Entraining Effect on Rheological Properties of Cement-Based Mixtures

open access: yesAdvances in Materials Science and Engineering
The rheological properties and stability of cement-based materials determine the technological properties of concrete mixtures and significantly influence concrete properties.
Aigerim Tolegenova   +3 more
doaj   +1 more source

Soil micromorphology for construction science: the mortar archaeometry [PDF]

open access: yes, 2012
Micromorphology revealed in depth evaluation of materials particularly soil micromorphology yielded numerous data on processes such as formation, neoformation and transformation of minerals and microstructure in soils, pottery and construction materials.
Akça, Erhan   +3 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Micromorphological description of vernacular cob process and comparison with rammed earth [PDF]

open access: yes, 2019
International audiencePast builders have developed very low-embodied energy construction techniques optimizing the use of local building materials. These techniques are a source of inspiration for modern sustainable building. Unfortunately, this know-how
Cammas, Cécilia   +4 more
core   +5 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Real-time Spatial Detection and Tracking of Resources in a Construction Environment [PDF]

open access: yes, 2006
Construction accidents with heavy equipment and bad decision making can be based on poor knowledge of the site environment and in both cases may lead to work interruptions and costly delays.
Bosche, Frederic Nicolas   +3 more
core  

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