Results 81 to 90 of about 3,108,657 (309)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Development of a web-based information system for cascading utilisation of construction materials

, 2003
This paper presents a Web-based information system for promoting the cascading utilisation of construction materials in order to mitigate the increasing environmental pressure by the construction industry.
Itoh, Yoshito, Langston, Craig, Liu, Chunlu, Pun, Sung Kin, Treloar, Graham   +4 more
core  

Low-cost hot-air solar collector [PDF]

, 1975
System has only three components per cell. Cell parts are fabricated from readily available materials and, following a construction procedure which requires use of only simple handtools, can be mounted in place by one ...
Anthony, K. G., Herndon, E. P.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Numerical Evaluation Method of Hydraulic Circuits Including Devices That Stabilise Pressure

The Journal of Engineering
This study develops a numerical algorithm for unsteady fluid flow for short and long hydraulic systems, including various hydraulic devices in the system, through scientific searches for new ways to protect long pipeline systems from sudden pressure ...
Paschal Chimeremeze Chiadighikaobi, Fedor V. Rekach, Svetlana L. Shambina, Yuri V. Belousov, Vladimir Jean Paul, Evgeny K. Sinichenko, Ilya I. Gritsuk, Andrey A. Anismov   +7 more
doaj   +1 more source

CONSTRUCTION ENGINEERING AND CONSTRUCTION MATERIALS

EPRA International Journal of Multidisciplinary Research (IJMR), 2019
Construction Engineering is very important part of Civil Engineering. We can’t think about a good and stable structure without good quality of construction. And the construction materials is also play an important role for any construction work. Construction engineering is a professional discipline that deals with the designing, planning, construction ...
openaire   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Use of Strain-Hardening Cement-Based Composites (SHCC) for Retrofitting

MATEC Web of Conferences, 2018
Strain-hardening cement-based composites (SHCC, or Engineered Cementitious Composites, ECC) were developed in the early 1990th and have been since then an object of numerous investigations which number increases every year.
Müller Steffen, Mechtcherine Viktor
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source