Results 111 to 120 of about 26,640,468 (347)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Packaging concept for LSI beam lead integrated circuits [PDF]

, 1972
Development of packaging system for mounting beam lead integrated chip circuit on lead frame is discussed. Process for fabricating large scale integration circuits is described.
Kennedy, B. W.
core   +1 more source

An Application of Analytic Hierarchy Process (AHP) for Sustainable Procurement of Construction Equipment: Multicriteria-Based Decision Framework for Malaysia

Mathematical Problems in Engineering, 2019
Sustainable procurement is an emerging theme in the construction industry across the globe. However, organizations in the construction industry often encounter impediments in improving environmental performance in construction projects, especially in ...
M. Waris, S. Panigrahi, A. Mengal, M. Soomro, N. H. Mirjat, Mehfooz Ullah, Zarith Sufia Azlan, Asadullah Khan   +7 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

CharacterMeet: Supporting Creative Writers' Entire Story Character Construction Processes Through Conversation with LLM-Powered Chatbot Avatars

International Conference on Human Factors in Computing Systems
Support for story character construction is as essential as characters are for stories. Building upon past research on early character construction stages, we explore how conversation with chatbot avatars embodying characters powered by more recent ...
Hua Xuan Qin, Shan Jin, Ze Gao, Mingming Fan, Pan Hui   +4 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Implementation of critical success factors in construction research and development process [PDF]

, 2010
Construction research and development (R&D) process has a number of issues that affect its success. These issues imply that Critical Success Factors (CSFs) of construction R&D process are not properly addressed.
Amaratunga, RDG, Haigh, RP, Kulatunga, U
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Monitoring of construction processes in the variable environment / Statybos procesų stebėsena kintančioje aplinkoje

Technological and Economic Development of Economy, 2008
Interference problems of construction processes are especially disturbing due to their big scope of variability, uncertainty and complexity what significantly hinders planning and accomplishing the production processes on the building site. Monitoring of
Andrzej Karlowski, Jerzy Paslawski
doaj   +1 more source

A parameterization process as a categorical construction

, 2009
The parameterization process used in the symbolic computation systems Kenzo and EAT is studied here as a general construction in a categorical framework.
Dominguez, César, Duval, Dominique
core   +2 more sources