Results 151 to 160 of about 847,107 (317)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Investigating learning in construction organizations [PDF]

open access: yes, 2005
Learning in construction has received scant attention within extant theories of generic organizational learning. One of the apparently distinct characteristics of construction organization is that its business mainly runs through projects.
Hogg, Keith   +3 more
core  

Using a meshless method to investigate the effects of confining pressure on the hydraulic fracturing processes of hydraulic tunnels

open access: yesScientific Reports
To reveal the dynamic evolution mechanism of hydraulic fracturing in hydraulic tunnels under different confining pressures and overcome the limitations of traditional tests and numerical methods in simulating complex crack propagation and multi-field ...
Haichen Zhang   +7 more
doaj   +1 more source

Project financing in construction projects

open access: yes, 2020
Proje Finansmanı, uzun vadeli alt yapı, endüstriyel veya büyük çaptaki projelerin kamu projelerinin yapımı için sağlanan kredi olarak tanımlanmaktadır. Bu finansman modelinde, diğer finansman modellerinden farklı olarak, kredi geri ödemesi için gipotek edilen kaynaklar krediyi kullanan tarafın varlıkları değil, projeden elde edilecek olan nakit ...
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Case study of the National Museum (Action Peninsula) project [PDF]

open access: yes, 2000
The Acton Peninsula project alliance is the first project alliance in building construction in the world. The project alliance is set out to achieve the best possible outcome for the project with all participants in the alliance sharing both risks and ...
Hampson, Keith D.   +2 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Measuring the associations between collaborative working and project performance [PDF]

open access: yes, 2009
There is evidence that higher degrees of collaborative working can produce more successful project performance, but there is only limited research to systematically examine the specific associations between collaborative working and project performance ...
Greenwood, David   +2 more
core  

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