Results 151 to 160 of about 845,765 (317)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Using a meshless method to investigate the effects of confining pressure on the hydraulic fracturing processes of hydraulic tunnels

Scientific Reports
To reveal the dynamic evolution mechanism of hydraulic fracturing in hydraulic tunnels under different confining pressures and overcome the limitations of traditional tests and numerical methods in simulating complex crack propagation and multi-field ...
Haichen Zhang, Yanran Shi, Juan Mu, Ruifu Hao, Dunzhe Qi, Wei Li, Bufan Zhang, Shuyang Yu   +7 more
doaj   +1 more source

Health and Safety in Temporary Work Zone Road Construction Project in Saudi Arabia: Risks and Solutions. [PDF]

Int J Environ Res Public Health, 2022
Alsultan SM, Alqahtani FK, Alkahtani KF.
europepmc   +1 more source

Project financing in construction projects

, 2020
Proje Finansmanı, uzun vadeli alt yapı, endüstriyel veya büyük çaptaki projelerin kamu projelerinin yapımı için sağlanan kredi olarak tanımlanmaktadır. Bu finansman modelinde, diğer finansman modellerinden farklı olarak, kredi geri ödemesi için gipotek edilen kaynaklar krediyi kullanan tarafın varlıkları değil, projeden elde edilecek olan nakit ...
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A construction project scheduling methodology considering COVID-19 pandemic measures. [PDF]

J Safety Res, 2022
Aslan S, Türkakın OH.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Virtual construction project management environment

, 2018
The focus of this research project was to develop a virtual Construction Project Management (CPM) environment to enhance the educational outcomes for learners in the discipline of Construction Management.
Kahkonen, K., Kestle, Linda, Davies, Kathryn, Puolitaival, Taija, Forsythe, P.   +4 more
core  

Concepts of constructability for project construction in Indonesia

IOP Conference Series: Materials Science and Engineering, 2019
Abstract A study of constructability has recently become one of the research themes that has received much attention. Constructability can be defined as the application and integration of construction knowledge and experience to the process of planning, designing, procuring and implementing construction.
openaire   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source