Results 141 to 150 of about 845,765 (317)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Construction management abstracts : cumulative abstracts and indexes of journals in construction management, 1983-2000

open access: yes, 2000
The purpose of this document is to provide a single source of reference for every paper published in the journals directly related to research in Construction Management. It is indexed by author and keyword and contains the titles, authors, abstracts
Hughes, Will   +1 more
core  

Lean construction in road projects

open access: yes, 2018
By far civil engineering represents one of the fields with lower productivity. This fact can be explained by a number of reasons, such as the lack of standardization in their projects, insufficient attention to building details or inadequate automation.
Elkherbawy, Ahmed   +3 more
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Final report : your building

open access: yes, 2007
The Your Building Project to build a website as the business and technical guide to\ud sustainable commercial buildings has now been completed. The site is available at\ud www.yourbuilding.org.

core  

Management of contractor's claim in Turnkey projects according to FIDIC under termination and dissolution of contract [PDF]

open access: yesمهندسی و مدیریت ساخت, 2019
Generally, increasing complexity of the structural stages of the contracts and contracting conditions as well as inconvenient conditions of projects including Meteorological, political, and leads to intensification of disputes, claims and litigation ...
Amir Momeni, Mohsen Heidari
doaj  

Impact of Pandemic SARS COVID-19 on Different Construction Project Management: Problems and Solutions. [PDF]

open access: yesPublic Works Manag Policy, 2023
Waheeb RA   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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