Results 141 to 150 of about 847,107 (317)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Brite innovation survey : executive summary [PDF]

open access: yes, 2005
This report summarises the fi ndings of an innovation survey\ud of the Australian construction industry undertaken by the\ud BRITE Project of the CRC for Construction Innovation in\ud 2004.

core  

Evaluation of Skid Resistance and Comfort of Pedestrian Pavement with Asphalt-Based Wood Chip

open access: yesBuildings
This paper conducts an in-depth study and evaluation of pedestrian paths, with a particular focus on the anti-slip performance and walking comfort of wooden chip pedestrian walkways.
Jian Ma   +9 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Business Drivers for BIM [PDF]

open access: yes, 2007
his report describes in detail a project aimed at providing a better understanding of the business drivers and barriers to the adoption of Building Information Modelling (BIM) in the Architecture Engineering and Construction (AEC) and facility management

core  

Impact of Pandemic SARS COVID-19 on Different Construction Project Management: Problems and Solutions. [PDF]

open access: yesPublic Works Manag Policy, 2023
Waheeb RA   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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