Results 121 to 130 of about 13,014,672 (303)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Constructions for projectively unique polytopes
Discrete Mathematics, 1976 AbstractA convex polytope P is projectively unique if every polytope combinatorially isomorphic to P is projectively equivalent to P. In this paper are described certain geometric constructions, which are also discussed in terms of Gale diagrams. These constructions are applied to obtain projectively unique polytopes from ones of lower dimension; in ...
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Advancing Circular Buildings: A Review of Building Strategies for AEC Stakeholders
BuildingsThe uptake of a circular economy (CE) in the building sector is challenging, primarily due to the complexity associated with the design process and the dynamic interaction among architects, engineers, and construction (AEC) stakeholders. The standard and
Mohana Motiei +3 more
doaj +1 more source
Retracted: Value Proposition for Enabling Construction Project Innovation by Applying Building Information Modeling. [PDF]
Comput Intell Neurosci, 2023 Intelligence And Neuroscience C.
europepmc +1 more source
PROJECT SCORECARD IN CONSTRUCTION PROJECTS
, 2009 This paper describes performance measurement methodology of construction projects from construction company view. Traditional performance indicators (time, cost, quality) are not sufficient for balanced view of project success or fail. They are lagging indicators because they constitute results of project execution and do not show drivers performance ...
Katić, Dragan, Bevanda, Ladislav
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Implementation Experience of COVID-19 Rapid Antigen Testing in a Large-Scale Construction Project in Victoria, Australia. [PDF]
Glob Implement Res Appl, 2023 Ludwick T +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A framework for assessing social policy inclusion proposals [PDF]
, 2009 This document outlines a framework that could be used by government agencies in assessing policy interventions aimed at achieving social outcomes from government construction contracts.
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