Results 111 to 120 of about 3,501,488 (306)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Advancing Circular Buildings: A Review of Building Strategies for AEC Stakeholders

Buildings
The uptake of a circular economy (CE) in the building sector is challenging, primarily due to the complexity associated with the design process and the dynamic interaction among architects, engineers, and construction (AEC) stakeholders. The standard and
Mohana Motiei, Usha Iyer-Raniga, Mary Myla Andamon, Ania Khodabakhshian   +3 more
doaj   +1 more source

A constructive real projective plane

Journal of Geometry, 2015
The classical theory of plane projective geometry is examined constructively, using both synthetic and analytic methods. The topics include Desargues's Theorem, harmonic conjugates, projectivities, involutions, conics, Pascal's Theorem, poles and polars.
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Impact of Thrombolysis Time Metrics When Participating in National Stroke Center Construction Project. [PDF]

J Multidiscip Healthc, 2023
Cheng W, Mofatteh M, Baizabal-Carvallo JF, Lu S, Su P, Chen Y, Li L, Qin L, Zuo X, Lan Y, Huang Y, Yu Z, Luo Z, Chen G.   +13 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Credit analysis policies in construction project finance [PDF]

This paper aims to illustrate a revolutionary approach to bank financing of extensive investment projects developed by major corporations. The new approach pertains to corporate banking and is applied to corporate projects developed by special purpose ...
Alina Mihaela DIMA, Andra–Maria VASILESCU, Simona VASILACHE   +2 more
core  

Risk pricing practices in finance, insurance and construction [PDF]

, 2008
A review of current risk pricing practices in the financial, insurance and construction sectors is conducted through a comprehensive literature review.
Laryea, Samuel
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Retracted: Value Proposition for Enabling Construction Project Innovation by Applying Building Information Modeling. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source