Results 71 to 80 of about 3,483,321 (306)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

An experience of introducing last planner into a UK construction project [PDF]

open access: yes, 2003
The Last Planner methodology developed by the Lean Construction Institute is a production control tool which has possible benefits for improving planning in the UK construction industry. Its application has been considered in countries outside the UK but
Johansen, Eric, Porter, Geoff
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

General systems perspective on achieving continuous synergy in a project organisation [PDF]

open access: yes, 2007
Studies of construction labour productivity have revealed that limited predictability and multi-agent social complexity make long-range planning of construction projects extremely inaccurate.
Radosavljevic, Milan
core  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Abandoned project restoration model (APRM) for residential construction projects [PDF]

open access: yes, 2017
Incompletion of construction projects is a common phenomenon in Malaysia. Project abandonment has given an adverse consequences to the economy, society and environment. In the best interest of the end users and other parties involved in the contract, the
Doraisamy, Sanitha V.
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Self-adaptive Adjustment of Shield Tunneling Parameters and Land Subsidence Control Based on Regional Geological Information

open access: yesChengshi guidao jiaotong yanjiu
Objective At present, it has become a trend that the method of machine learning is used to predict land subsidence. However, most of the land subsidence prediction models established based on geological parameters and shield tunneling parameters are ...
CAO Tiejun
doaj   +1 more source

Home - About - Disclaimer - Privacy