Results 141 to 150 of about 1,904,922 (309)
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Management of Contractor’s Claims in Construction Projects
Littera Scripta, 2013 The main objective of this work is to suggest a suitable way for efficient implementation of a Contractor’s Claim Management system in construction companies in CEE countries.
Lukáš Klee
doaj
CRITICAL SUCCESS FACTORS THAT INFLUENCING SAFETY PROGRAM PERFORMANCE IN MALAYSIAN CONSTRUCTION PROJECTS: CASE STUDIES [PDF]
The construction industry is characterized as one with a poor safety culture globally. To achieve better site safety performance, emphasis has been placed on implementing effective safety programs.
ABDELNASER OMRAN +2 more
core
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
THE INVESTMENT PROJECT PIPELINE COST ESCALATION, LEAD-TIME, SUCCESS, FAILURE AND SPEED1 [PDF]
As they involve expectations about the future and long lead times for planning and construction, the evolution of investment projects is usually complex and volatile.
Jiawei Si, Kenneth W Clements
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Structural Behavior of Voided Fibrous Sustainable Ferrocement Slabs
Journal of EngineeringThe global trend at the present time focuses on reducing waste resulting from daily uses and those resulting from manufacturing processes and others, and one of the effective means of reducing waste is to reuse it in concrete in various forms such as ...
Bashar H. Ismael +5 more
doaj +1 more source