Results 91 to 100 of about 5,487,587 (291)

Simulation of virtual time norms for technological processes

open access: yesJournal of Business Economics and Management, 2003
The methodology presented in the article is based on the simulation of technological process duration, restricting on the available information about total duration of complex technological process in the conditions when there are no possibilities to ...
Romualdas Tamošaitis   +1 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Improving Transportation Construction Project Performance: Development of a Model to Support the Decision-Making Process for Incentive/Disincentive Construction Projects, MTI Report 09-07 [PDF]

open access: yes, 2010
This research presents a project time and cost performance simulation model to assist project planners and managers by providing a complete picture during the Incentive/Disincentive (I/D) contracting decision-making process of possible performance ...
Park, Taeho, Pyeon, Jae-Ho
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

A time marker instrument for kinematics movement studies: a development of previous versions

open access: yesSemina: Ciências Exatas e Tecnológicas, 2009
This article presents a time marker to study movements in kinematics. It contributes to elaborate a version of time marker which low cost and more efficient in comparison with the marker presented in another work as well as the earlier commercial version.
Carlos Eduardo Laburú   +1 more
doaj  

Five-Year Epidemiological Study and Estimation of Accidents Distribution in Construction Industry Workers in Yazd City by the Year 2011 by Applying Time Series Model [PDF]

open access: yesJournal of Kerman University of Medical Sciences, 2009
Background & Aims: Occupational accidents are known as one of the most important causes of disabilities and mortality in developed and developing countries.
A Bahrampour   +2 more
doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

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