Results 81 to 90 of about 17,997,904 (297)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Construction: Notes on Qualitative Time and Space
Pensamiento. Revista de Investigación e Información Filosófica, 2015 The conceptual definition of time and space has given rise to some difficulties in classical philosophy. These difficulties worsen with reference to time, which is presented as an «obscure idea». The root of the problem lies in considering time and space
José Antón Pacheco
doaj
Alexandria Engineering Journal, 2013 The construction projects involve various risk factors which have various impacts on time objective that may lead to time-overrun. This study suggests and applies a new technique for minimizing risk factors effect on time using lean construction ...
Usama Hamed Issa
doaj +1 more source
Effect of three different needle holders on gastrointestinal anastomosis construction time and bursting pressure in equine jejunal segments. [PDF]
BMC Vet Res, 2021 Averay K +3 more
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
COST AND TIME CONTROL DURING PLANNING AND CONSTRUCTION STAGES IN CONSTRUCTION PROJECTS
Al-Qadisiyah Journal for Engineering Science, 2011 This research aims to develop time scheduling model including time cost trade off analysis, resource leveling and cash flow management during planning stage and project control during construction stage.
Ibtisam Mohammed Ali
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Acta Structilia, 2012 The estimation of contract completion time has always been inaccurate despite there being a need for certainty regarding the completion of projects. This article reports on an investigation of the relationship between initial and final contract time with
Olatunji Ayodeji Aiyetan +2 more
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