Results 161 to 170 of about 275,467 (315)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
German participle II constructions as adjuncts
, 2013 The present investigation is concerned with German participles II (past participles) as lexical heads of adjuncts. Within a minimalist framework of sound-meaning correlation, the analysis presupposes a lexicalist conception of morphology and the ...
Zimmermann, Ilse
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
, 2014 This article has two main objectives. The first is to outline the basic design of the system of expressing comparisons in Swedish sentences from a functional point of view. Comparisons occur in various dimensions: identity, likeness, grading, preference,
Hammarberg, Björn,
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Studies in ditransitive constructions
, 2017 This rich volume explores the cross-linguistic variation in ditransitive constructions, syntactic patterns of 'give'-like verbs taking Agent, Theme and Recipient ...
Fedden, S
core +1 more source
A construction grammar account of possessive constructions in Lancashire dialect : some advantages and challenges. [PDF]
, 2007 This study investigates reduction of 1SG possessives in possessive–noun constructions in Lancashire dialect. On the basis of a corpus of twenty-six interviews we show that reduction patterns according to (in)alienability.
Siewierska, Anna, Hollmann, Willem B.
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Ditransitive constructions in Cantonese: the give-construction as the non-prototypical example
, 2007 INTRODUCTION : 1. The default definition for a ditransitive construction is almost invariably ‘a construction like the give-construction’. 2. While the give-construction is the most representative example of such constructions in most languages, this is ...
Lam, OSC
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