Results 71 to 80 of about 77,261 (266)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
EMBO reports, 2023 A fundamental tenet of the scientific process is that science is self‐correcting. Efficient correction of the scientific literature requires a more nuanced set of policies and tools that lower the bar to author self‐correction. The community has to embrace correction as a signal of scholarly quality.
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Research of Temperature and Moisture during Sitting on Office Chairs
Drvna Industrija, 2012 When using an office chair, a person comes into direct contact with the seat, where the contact surface creates a microclimate that affects the person’s positive or negative mood, depending on temperature and humidity.
Zoran Vlaović +2 more
doaj
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Finite element models in stresses for bending plates
Инженерно-строительный журнал, 2018 Finite element models for plate bending problems are constructed on the basis of approximations of moments fields. The bending and twisting moments are approximated in the finite element area by piecewise constant functions.
Yury Tyukalov
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Autonomous Robots, 2006 [abstFig src='/00280002/01.jpg' width=""300"" text='A humanoid robot riding an excavator' ]The following article reviews past and current tendencies and derives and describes opportunities for construction robotics and automation. There substantial evidence in the construction industry, that conventional construction methodology has reached its limits.
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