Results 81 to 90 of about 162,917 (315)

Design reuse in a CAD environment

open access: yes, 1999
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 09/03/1999.For many companies, design related information mainly exists as rooms of paper-based archives, typically in the form of manufacturing drawings ...
Andrews, Peter TJ
core  

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

open access: yesAdvanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang   +16 more
wiley   +1 more source

Modern construction machines as an element of an innovative architectural process

open access: yesДороги і мости
Introduction. The modern architectural and construction process is undergoing significant changes under the influence of digital transformation, automation and the development of innovative technologies.
Olga Vasylyshyn   +2 more
doaj   +1 more source

Parametric Surfaces and Architecture: Concepts, Design, and Production

open access: yes, 2005
By incorporating parametric surfaces and spline entities into the shape modeling computer systems, new design and production graphic tools have been created in the conceptual and poetic field of architecture; thus allowing an intuitive approach to the ...
M. Chiarella
core  

Computer aided parametric design of hydraulic gear pumps [PDF]

open access: yes, 2017
This paper addresses methodological and applied issues to design spur gear pumps. Based on the requirements raised by a Romanian production partner, the overall objective of this research is to identify several design alternatives and to propose improved
JAMSHED, Iqbal   +6 more
core  

Perspective: Hollow Core Optical Fibres for Ultraviolet and Visible Wavelengths

open access: yesAdvanced Science, EarlyView.
Hollow core optical fibres bypass material constraints that limit optical fibres at ultraviolet and visible wavelengths. However, their challenging fabrication has limited their development, and significant gains in performance remain possible. In this perspective we outline approaches to enable the next generation of fibres for shorter wavelengths ...
Robbie Mears   +5 more
wiley   +1 more source

Designing with Priorities and Thresholds for Health Care Heterogeneity: The Approach of Constructing Parametric Ontology

open access: yes, 2015
Designing systems working in health care needs complying with the heterogeneous, overlapping, non-overlapping, competing, or even contradicting requirements expressed by the various actors of the health care complex environment, including regulatory bodies.
Eivazzadeh, Shahryar   +3 more
openaire   +3 more sources

Substatiation of the constructive-technologocal parameters of a solar fruit dryer

open access: yes, 2017
A design of solar dryer for fruit drying is proposed, which includes the use of a flat mirror concentrator – to enhance the slanting flows of morning and evening solar radiation, and a thermal battery based on pebble for the accumulation during night ...
Serhiy Korobka, M. Babych
semanticscholar   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

open access: yesAdvanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza   +9 more
wiley   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

open access: yesAdvanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao   +7 more
wiley   +1 more source

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