Results 71 to 80 of about 551,324 (261)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Were the Online Training Courses Imparted to Consultants in the COVID Era Really Effective? [PDF]

open access: yesInterdisciplinary Journal of Virtual Learning in Medical Sciences, 2022
Ruchika Garg, Akhil Singh
doaj   +1 more source

Factors affecting the performance of construction projects in the Gaza strip

open access: yesJournal of Civil Engineering and Management, 2009
Construction projects located in the Gaza Strip, Palestine suffer from many problems and complex issues. Consequently, the objective of this paper is to identify the factors affecting the performance of local construction projects; and to elicit ...
Adnan Enshassi   +2 more
doaj   +1 more source

Target Markets for Grain and Cotton Marketing Consultants and Market Information Systems [PDF]

open access: yes
This paper examines the use of market consultants and market information systems by grain and cotton producers. A model of producer demand for marketing information and consultants is proposed that decomposes price received into exogenous and endogenous ...
Baquet, Alan E.   +5 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Residents and Consultants Have Equal Outcomes When Performing Transrectal Fusion Biopsies: A Randomized Clinical Trial

open access: yesCurrent Oncology
The aim of our study was to compare the performance of residents vs. consultants in transrectal fusion prostate biopsies (FUS-PBs), as well as patient-reported comfort.
Beatrice Turchi   +11 more
doaj   +1 more source

What Works? A Study of Effective Early Childhood Mental Health Consultation Programs [PDF]

open access: yes, 2009
Examines factors that lead to desirable outcomes in mental health consultation programs: solid program infrastructure, highly qualified consultants, and quality support services.
Bruno Anthony   +6 more
core  

Factors impeding the industrialized building system (IBS) implementation of building construction in Malaysia [PDF]

open access: yes, 2018
In Malaysian construction industry, Industrialised Building System (IBS) has been introduced to replace the traditional construction method. While the government has been making significant efforts to encourage the IBS adoption, the uptake of IBS in ...
Abas, Nor Ain   +3 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

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