Results 41 to 50 of about 944,347 (309)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Anthelmintic resistance against benzimidazoles and macrocyclic lactones in strongyle populations on cattle farms in northern Germany

Scientific Reports
Anthelmintic resistance (AR) in cattle gastrointestinal nematodes (GIN) is an increasing global concern, with low to moderate levels recently documented in Central Europe.
Paula Ehnert, Jürgen Krücken, Stefan Fiedler, Fabian Horn, Christina S. Helm, Ann Neubert, Wiebke Weiher, Werner Terhalle, Stephan Steuber, Ricarda Daher, Georg von Samson-Himmelstjerna   +10 more
doaj   +1 more source

RADIATION CONDITIONS IN KALUGA REGION 30 YEARS AFTER CHERNOBYL NPP ACCIDENT

Радиационная гигиена, 2016
The article describes radiation conditions in the Kaluga region 30 years after the Chernobyl NPP accident. The Chernobyl NPP accident caused radioactive contamination of nine Kaluga region territories: Duminichsky, Zhizdrinsky, Kuibyshevsky, Kirovsky ...
A. G. Ashitko, D. V. Zolochevskiy, O. V. Ovsyannikova, S. A. Rozhkova   +3 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Radiation conditions in the Oryol region territory impacted by radioactive contamination caused by the Chernobyl NPP accident

Радиационная гигиена, 2016
Research objective is retrospective analysis of radiation conditions in the Oryol region during 1986- 2015 and assessment of efficacy of the carried out sanitary and preventive activities for population protection against radiation contamination caused ...
G. L. Zakharchenko, E. N. Pereverzeva, A. A. Vasilev, E. V. Polyakova, S. N. Milovanov   +4 more
doaj   +1 more source

Study on Antiviral Activity and Pharmacological Safety of Double-Stranded Ribonucleic Acid for Intranasal Administration

Антибиотики и Химиотерапия, 2022
Interferon inducers are of interest as the first line of defense against viral infections, including influenza. Double-stranded ribonucleic acid (dsRNA) for intranasal administration has been developed, the excipients and drug components were selected at
S. G. Gamaley, G. G. Shimina, E. S. Tsyplenkova, O. V. Simakova, M. O. Skarnovich, M. A. Skarnovich, L. N. Shishkina, O. S. Taranov, O. S. Ivanova, G. M. Levagina, E. D. Danilenko   +10 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Genetic features of the Puumala virus (Hantaviridae: Orthohantavirus) identified in the Moscow region

Вопросы вирусологии, 2023
Introduction. Puumala virus (family Hantaviridae, genus Orthohantavirus) is distributed in most regions of the European part of Russia. However, information about its genetic variants circulating on the territory of the Central Federal District is ...
Ekaterina A. Blinova, Marat T. Makenov, Evgeny S. Morozkin, Ivan S. Kholodilov, Marina V. Fedorova, Olga B. Zhurenkova, German V. Roev, Kamil F. Khafizov, Ludmila S. Karan   +8 more
doaj   +1 more source

Consumer Advisory Bulletin, Guard Your Bank Accounts!, June 2005 [PDF]

, 2005
The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments.

core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source