Results 41 to 50 of about 285,348 (268)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

EPIDEMIOLOGICAL RISK OF INTRODUCTION OF DANGEROUS AND EXOTIC INFECTIOUS DISEASES ON THE TERRITORY OF THE XXII OLYMPIC WINTER GAMES AND XI PARALYMPIC WINTER GAMES 2014 IN SOCHI

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
To assess the epidemiological risk of introduction of serious infectious diseases in the pre-Olympic period defined list of dangerous and exotic infections and held assessment ofpotential danger threatening.
B. P Kuzkin, E. B Ezhlova, A. N Kulichenko, O. V Maletskaya, Yu. V Demina, T. V Taran, N. D Pakskina, T. V Kharchenko, G. M Grizhebovsky, V. N Savelev, V. G Oroby, V. P Klindukhov, T. V Grechanaya, S. Ch Tesheva, G. D Bryukhanova   +14 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Innovations and risk in entrepreneurship

Путеводитель предпринимателя, 2020
In article theoretical aspects of business activity in the innovative environment in which the risk and uncertainty are inherent are considered.
Y. V. Sakharnov
doaj  

Morbidity Rates of Q Fever in the Russian Federation and European Countries: Realities and Problems

Проблемы особо опасных инфекций, 2015
Q fever poses a problem, both in the Russian Federation and abroad. Thereat, a new base normative document, sanitary-epidemiological regulations on coxiellosis prevention, has been developed and approved in the Russian Federation. For the first time ever
E. A. Yakovlev, S. V. Borisevich, A. Yu. Popova, E. B. Ezhlova, Yu. V. Demina   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

PRINCIPLE DIRECTIONS FOR THE CREATION AND ORGANIZATION OF THE SYSTEM OF SANITARY-EPIDEMIOLOGICAL SAFETY DURING THE PREPARATIONS FOR THE XXII OLYMPIC WINTER GAMES AND XI PARALYMPIC WINTER GAMES 2014 IN SOCHI

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
The paper generalizes the experience of formation of protection system against biological threats and ensuring sanitary and epidemiological welfare during preparation for the XXII Olympic Winter Games and XI Paralympic Winter Games of 2014 in Sochi.
G. G Onischenko, I. V Bragina, E. B Ezhbva, Yu. V Demina, A. A Gorsky, A. S Guskov, O. I Aksenova, G. E Ivanov, V. P Klindukhov, P. N Nikolaevich, T. V Grechanaya, A. N Kulichenko, O. V Maletskaya, E. A Manin, V. V Parkhomenko, O. A Kulichenko   +15 more
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Epidemiological Features of New Coronavirus Infection (COVID-19). Communication 1: Modes of Implementation of Preventive and Anti-Epidemic Measures

Проблемы особо опасных инфекций, 2020
The review analyses the information on the epidemiological situation on COVID-19 around the world. Presented is the assessment of the major epidemiological parameters (basic reproductive rate, lethality, incubation period, and serial interval ...
V. V. Kutyrev, A. Yu. Popova, V. Yu. Smolensky, E. B. Ezhlova, Yu. V. Demina, V. A. Safronov, I. G. Karnaukhov, A V. Ivanova, S. A. Shcherbakova   +8 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source