Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
The contact hypothesis re-evaluated
This paper evaluates the state of contact hypothesis research from a policy perspective. Building on Pettigrew and Tropp's (2006) influential meta-analysis, we assemble all intergroup contact studies that feature random assignment and delayed outcome ...
E. Paluck, S. Green, Donald P. Green
semanticscholar +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Absence of COVID-19 workplace transmission from hairdressers in Victoria, Australia
Ericka Swaney +4 more
doaj +1 more source
Ultralow contact resistance between semimetal and monolayer semiconductors
Pin-Chun Shen +22 more
semanticscholar +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Gravity Models of Internal Migration – the Czech Case Study
In this paper, the models of internal migration flows between regions (NUTS 3) in the Czech Republic in time series from 1991 to 2012 are tested. The paper aims to find out how size, distance and economic variables explain migration flows between Czech ...
Jandová Monika, Paleta Tomáš
doaj +1 more source
SENSE OF PLACE AND BELONGING IN SORLEY MACLEAN’S POETRY
Sense of place and belonging in Sorley MacLean’s Poetry. Placing himself in the wake of Hugh MacDiarmid’s Scottish Renaissance, Sorley MacLean initiated the Gaelic Renaissance with the same aim in view.
Daniela ROGOBETE
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source

