Results 111 to 120 of about 3,549,018 (318)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Current patch test results with the European baseline series and extensions to it from the 'European Surveillance System on Contact Allergy' network, 2007-2008 [PDF]

, 2012
BACKGROUND: The pattern of contact sensitization to the supposedly most important allergens assembled in the baseline series differs between countries, presumably at least partly because of exposure differences. Objectives.
Jolanki, Riitta, Sansom, J.E., Beliauskiene, Aiste, Ormerod, Ad, Simon, D, Ballmer Weber B, Statham, Bn, Fuchs, T, Schuttelaar, Marie-Louise, Uter, W, Chowdhury, M.M., Sansom JE, Elsner, P., Sánchez-Pérez, Javier, Czarnecka-Operacz, Magda, English, Js, Fortina, Anna Belloni, Uter, W., Ormerod AD, García-Gavín J, Elsner, Peter, Rantanen, Tapio, Cooper, Sue, Fernandez-Redondo, V., García Gavín, J, Spiewak R, Gawkrodger, David J., Uter, Wolfgang, Ayala, Fabio, Fuchs, Thomas, Zmudzinska M, Bircher A, Sánchez-Pérez J, Carlos Armario-Hita, Jose, Kiec-Swierczynska M, Coenraads PJ, Sansom, Je, Aberer W, Larese, F., Fortina AB, Chowdhury, Mahbub M U, Fernández-Redondo V, Ballmer-Weber, Barbara, Giménez Arnau A, Brasch, J, Chowdhury, Mm, Schnuch, Axel, Gawkrodger, Dj, Brasch J, Balato, A, Aberer, W., Fernandez Vozmediano JM, Johansen JD, Fernández-Redondo, Virginia, Coenraads, Pieter-Jan, Green, Cathy M., Horne, Hl, Cooper, S., Brasch, Jochen, Mahler, Vera, Pesonen, M., Pesonen, Maria, Fernandez-Vozmediano, J.M., LARESE FILON, FRANCESCA, Giménez Arnau, A, Jolanki, R., English JS, Fernandez-Vozmediano JM, Fernández Redondo, Virginia, Rustemeyer, T., Schuttelaar, Marie-Louise; id_orcid, García Gavín J, Rantanen T, Coenraads, P.J., Armario-Hita JC, Fernandez-Vozmediano, Jose M., Ayala F, Garcia-Gavin, J., Mahler, V, Armario Hita JC, Aberer, Werner, Wilkinson M, Coenraads, Pj, Silvestre, J.F., Schnuch A., Balato, Anna, Elsner P, Sánchez Pérez J, Schuttelaar, Ml, Ormerod, Anthony D, Statham BN, Armario-Hita, José Carlos, Bauer, Andrea, Giménez-Arnau, Ana, Stone, N., Fernandez-Vozmediano, José M, Armario-Hita, J.C., Spiewak, R., Mahler V, Ballmer-Weber, B., Balato A, Green CM, Chomiczewska, D., Silvestre, Juan Fco, Fernández Redondo V, Fernández Redondo, V, Peserico, A, Sansom, Jane E, Chowdhury, Mahbub M. U., Bircher, A., Larese F, Zmudzinska, Maria, Statham, Barry N, Horne, H.L., Beliauskiene A, Wilkinson, Mark, Frosch, P.J., Green, Cm, Ayala, F, Simon, Dagmar, Spiewak, R, Larese, Francesca, Cooper, S, Bauer A, Fernandez Vozmediano, Jm, King, C.M., Armario Hita, Jc, Cooper S, Krêcisz B, Stone, N, Frosch, Peter J., Kiec Swierczynska, M, Krêcisz, Beata, Sanchez-Perez, J., Kiec Swierczynska M, Sansom, Jane E., Frosch, Pj, Aberer, W, Beliauskiene, A, Fuchs, T., Pesonen, Sini Maria Aliina, King, Clodagh M, Statham, Barry N., Rustemeyer, T, Rantanen, T, Sánchez Pérez, J, Czarnecka Operacz M, Horne HL, Ballmer-Weber B, Fortina, Ab, Elsner, P, Pesonen M, Fortina, A.B., English, J.S., PESERICO STECCHINI NEGRI DE SALVI, ANDREA, Peserico A, Jolanki, R, Wilkinson, M, King, Clodagh M., Ormerod, A.D., Silvestre, Jf, Chomiczewska, Dorota, Rustemeyer, Thomas, Kiec-Swierczynska, Marta, Rantanen, T., Krecisz, B., Gimenez-Arnau, A., Peserico, Andrea, English, John S C, Frosch PJ, Jolanki R, Spiewak, Radoslaw, Brasch, J., Gawkrodger, D.J., Czarnecka-Operacz, M., Bircher, A, Simon D, Uter W, Rustemeyer T, Horne, Helen L, Chomiczewska, D, Johansen, J.D., Kiec-Swierczynska, M., English, J.S.C., Silvestre JF, Schuttelaar, M.L., García-Gavín, Juan, Ayala, F., Peserico, A., Mahler, V., Bircher, Andreas, Zmudzinska, M., Balato, A., Simon, D., Wilkinson, M., King CM, Zmudzinska, M, Pesonen, M, Johansen, Jeanne Duus, Giménez-Arnau A, Bauer, A., Chomiczewska D, Green, Cathy M, BELLONI, FORTINA ANNA, Chowdhury MM, Schuttelaar ML, Stone N, English, John S. C., Gawkrodger, David J, Czarnecka-Operacz M, Stone, Natalie, Frosch, Peter J, Ballmer Weber, B, Krêcisz, B, Statham, B.N., Johansen, Jd, Fuchs T, Horne, Helen L., King, Cm, Chowdhury, M.M.U., Beliauskiene, A., Gawkrodger DJ, Schnuch, A., Ormerod, Anthony D., Czarnecka Operacz, M, Green, C.M., Bauer, A   +226 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Absence of COVID-19 workplace transmission from hairdressers in Victoria, Australia

Public Health Research & Practice, 2022
Ericka Swaney, Brittany Murnane, Lauren Heard, N Deborah Friedman, Daniel P O'Brien   +4 more
doaj   +1 more source

Effect on oxides on surface topography and thermal contact resistance [PDF]

, 1979
The effect of oxides on the topographies of various random engineering surfaces and steady-state thermal contact resistances between oxidefree and oxidized metallic surfaces in contact in high vacua have been investigated. The results of many previous
Mian, M. N.
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A comparison of the predictions of a finite element model and multiscale model for a rough MEMS electrical contact

, 2013
Rough surface contact is difficult to model effectively due to multiple scales of detail that need to be considered. This work presents the results of a multiscale rough surface contact model in comparison to a finite element based deterministic model ...
Hong Liu, Dimitri Leray, Jackson, Robert L., Leray, Dimitri, Liu, Hong, Robert L. Jackson   +5 more
core   +1 more source

Changing the ideological roots of prejudice: Longitudinal effects of ethnic intergroup contact on social dominance orientation [PDF]

, 2014
Social Dominance Orientation (SDO) has been reported to be strongly related to a multitude of intergroup phenomena, but little is known about situational experiences that may influence SDO.
Hewstone, Miles, Hewstone, M, Dhont, K, Van Hiel, Alain, Van Hiel, A, Dhont, Kristof   +5 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source