Results 41 to 50 of about 329,608 (263)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala +8 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Osmocapillary phase separation at contact lines
Soft MatterThis paper shows that the solvent phase separation near the contact line of a swollen solid is governed by the competition between osmosis and capillary action instead of the commonly believed competition between elasticity and capillary action.
Qihan Liu, Luochang Wang
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Contact hypersurfaces in uniruled symplectic manifolds always separate [PDF]
Journal of the London Mathematical Society, 2014 24 pages, 1 figure; v.3 is a substantial expansion in which the semipositivity condition has been removed by implementing Cieliebak-Mohnke transversality; it also includes a new appendix to explain why the forgetful map in the Cieliebak-Mohnke context is a pseudocycle; v.4 has one short remark added; to appear in J.
openaire +3 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Surface separation in elastoplastic contacts
Physical Review EUnderstanding the contact between rough surfaces undergoing plastic deformation is crucial in many applications. We study the effect of plastic deformation on the surface separation between two solids with random roughness. Assuming a constant penetration hardness, we propose an iterative smoothing procedure (akin to elastoplastic “shakedown”) within ...
A. Almqvist, B. N. J. Persson
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Layered composite and contact layer. Normal separation and transversal strength
MATEC Web of Conferences, 2018 As well as testing adhesion joints, in which the average adhesion shear strength is measured, there are widespread methods of testing for normal separation, in which the value called transversal strength is measured. This value is calculated as the ratio
Andreev Vladimir +2 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source