Results 61 to 70 of about 329,608 (263)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Contact-separation-induced self-recoverable mechanoluminescence of CaF2:Tb3+/PDMS elastomer

Nature Communications
Centrosymmetric-oxide/polydimethylsiloxane elastomers emit ultra-strong non-pre-irradiation mechanoluminescence under stress and are considered one of the most ideal mechanoluminescence materials.
Wenxiang Wang, Shanwen Wang, Yan Gu, Jinyu Zhou, Jiachi Zhang   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Research on fabrics stack separation and transfer method based on Bernoulli suction cup non-contact grasping technology

Journal of Engineered Fibers and Fabrics
Separating fabrics stack using mechanical devices is considered a major obstacle to automation in garment processing due to their low density, low bending stiffness, and air permeability. To address this challenge, this paper discusses the feasibility of
Zihong Ma, Huimin Chen, Di Zhou, Mengmeng Ding, Xiaoli Yue   +4 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Dynamic osmocapillary phase separation at contact lines

Soft Matter
This paper shows that the size of solvent phase separation near the contact line of a swollen solid grows with time following the scaling t 0.32 at long time scales when the underlying deformation is linear.
Qihan Liu, Luochang Wang
openaire   +2 more sources

Study on the influence of near-fault vertical ground motion on the dynamic response of separation and collision of bridge

Scientific Reports
This study examines the contact nonlinear behavior of multi-span girder bridges in near-fault regions through dynamic analysis, evaluating the impact of seismic parameters such as excitation amplitude, period, and apparent wave velocity on structural ...
Xuerong Liu, Leilei Li, Yang Liu, Shuigen Chen, Wenjun An   +4 more
doaj   +1 more source

Vibration analysis of mistuned damped blades with nonlinear friction and contact

Journal of Low Frequency Noise, Vibration and Active Control, 2019
In general, only in tangential direction, friction motion between blade dampers is concerned for vibration analysis of mistuned bladed disk. However, in practical, excitation acting on blades inevitably causes normal movement at friction interface due to
Wei Zhao, Di Zhang, Yonghui Xie
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source