Results 131 to 140 of about 746,127 (308)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher   +10 more
wiley   +1 more source

Active Design of Contact Pattern and Experimental Verification of the Aero Spiral Bevel Gear

open access: yesJixie chuandong
In this study, an aero spiral bevel gear box is taken as the research object. An active design method for the bevel gear contact pattern is proposed. Firstly, the tooth surface design is carried out based on the macro parameters of spiral bevel gears and
Qian Lulu   +3 more
doaj  

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall   +16 more
wiley   +1 more source

Lubricated contact analysis of a spur gear pair with dynamic loads [PDF]

open access: yes
In the present research study, a comprehensive spur gear lubrication analysis has been carried out to understand the gear contact behaviour under lubrication conditions.
Liu, Huaiju
core  

Hydrogel contact lens ageing [PDF]

open access: yes, 2000
Purpose: To determine if hydrogel lens water content decreases over wearing periods of up to four weeks; that is, demonstrate an 'ageing' effect. Methods: Six subjects (4 males, 2 females; age range: 34.8 ± 11.0 years) wore each of the following lenses ...
Morgan, Philip B., Efron, Nathan
core  

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen   +7 more
wiley   +1 more source

Design of the Front Contact Metallization Patterns for Solar Cells Using Variable-Width Bezier Curves

open access: yesApplied Sciences
The pattern of the front contact metallization critically influences solar cell efficiency. This study introduces a novel explicit geometry optimization approach for designing the front contact metallization patterns.
Kai Li, Yongjiang Liu, Peizheng Li
doaj   +1 more source

Sibling placement and contact in out-of-home care [PDF]

open access: yes, 2015
Many children and young people do not live with all of their siblings in out-of-home care, and contact with the siblings who are not placed with them is not always regular or easily accessed, according to this report.
CREATE Foundation
core  

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz   +3 more
wiley   +1 more source

准双曲面齿轮齿面参数化方法研究

open access: yesJixie chuandong, 2005
A method to construct hypoid gear(HG) parameterized tooth surfaces with three types of parameters is presented.And their transformation relations have been demonstrated.The method is firstly utilized to refine the surface grid and to construct end curves.
王小林, 王延忠, 饶芳, 钟毅芳
doaj  

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