Results 31 to 40 of about 2,850,387 (254)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Strongly Nonlinear Waves in 3D Phononic Crystals [PDF]
, 2004 Three dimensional phononic crystal ("sonic vacuum" without prestress) was assembled from 137 vertical cavities arranged in hexagonal pattern in Silicone matrix filled with stainless steel spheres. This system has unique strongly nonlinear properties with
Daraio, C., Jin, S., Nesterenko, V.
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Man-machine communication - A transparent switchboard for computers [PDF]
, 1971 Device uses pattern of transparent contact touch points that are put on cathode ray tube screen. Touch point system compels more precise and unambiguous communication between man and machine than is possible with any other means, and speeds up operation ...
Rasmussen, H.
core +1 more source
, 2005 A nematic liquid crystal in contact with a grating surface possessing an alternating stripe pattern of locally homeotropic and planar anchoring is studied within the Frank--Oseen model.
Harnau, L. +2 more
core +1 more source
Tooth Contact Patterns at the Mandibular Retruded Contact Position
Nihon Hotetsu Shika Gakkai Zasshi, 2003 目的: 後方歯牙接触の顎機能に対する影響を検討する目的で, 健常有歯顎の被験者を対象として後方歯牙接触部位の記録を行い, これらの部位が歯列内においてどのように分布しているのかを分析した.方法: 被験者は健常有歯顎者283名とした. 術者は下顎の最後方位への誘導術式に十分習熟した歯科医師1名とし, 下顎頭が最後方位に誘導された際の歯牙接触部位に関して, 咬合紙を用いて記録した. 分析は, 接触歯の側性, 接触歯種, 接触歯数の3項目について, 接触歯群に基づく被験者の分類を加味して行った.結果: 1. 接触様式が両側性の被験者と片側性の被験者との比率は約6: 4であった. 2. 接触頻度の高かった接触歯種は, 第一小臼歯, 第二大臼歯の順であった. 3. 接触歯数は約8割の被験者で2歯以内であった.
Shuichiro Yamashita +3 more
openaire +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Capillary deformations of bendable films [PDF]
, 2013 We address the partial wetting of liquid drops on ultrathin solid sheets resting on a deformable foundation. Considering the membrane limit of sheets that can relax compression through wrinkling at negligible energetic cost, we revisit the classical ...
Adda-Bedia, M. +8 more
core +2 more sources