Results 31 to 40 of about 702,139 (267)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Textile-Based Weft Knitted Strain Sensors: Effect of Fabric Parameters on Sensor Properties

Sensors, 2013
The design and development of textile-based strain sensors has been a focus of research and many investigators have studied this subject. This paper presents a new textile-based strain sensor design and shows the effect of base fabric parameters on its ...
William Richard Kennon, Ozgur Atalay, Muhammad Dawood Husain   +2 more
doaj   +1 more source

Eyelid Pressure and Contact with the Ocular Surface [PDF]

Investigative Opthalmology & Visual Science, 2010
Purpose. To investigate static upper eyelid pressure and contact with the ocular surface in a group of young adult subjects. Methods. Static upper eyelid pressure was measured for 11 subjects using a piezoresistive pressure sensor attached to a rigid contact lens.
Shaw, Alyra, Collins, Michael, Davis, Brett, Carney, Leo   +3 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

German Society of Biomechanics (DGfB) Young Investigator Award 2019: Proof-of-Concept of a Novel Knee Joint Simulator Allowing Rapid Motions at Physiological Muscle and Ground Reaction Forces

Frontiers in Bioengineering and Biotechnology, 2019
The in vitro determination of realistic loads acting in knee ligaments, articular cartilage, menisci and their attachments during daily activities require the creation of physiological muscle forces, ground reaction force and unconstrained kinematics ...
Florian Schall, Andreas M. Seitz, Steffen Hacker, Stefan van Drongelen, Stefan van Drongelen, Sebastian I. Wolf, Anita Ignatius, Lutz Dürselen   +7 more
doaj   +1 more source

Sealing Performance of the End Fitting of a Marine Unbonded Flexible Pipe under Pressure Penetration [PDF]

Journal of Applied and Computational Mechanics, 2020
The sealing performance of end fittings is very important for offshore oil and gas pipelines. To investigate the sealing behavior of a ring-shaped wedge seal, global and local numerical models of the ring–pipe interaction have been developed based on the
Liping Tang, Wei He, Xiaohua Zhu, Yunlai Zhou   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Solution of contact pressure between robot edge with soft covering and human body surface considering nonlinear elasticity

Nihon Kikai Gakkai ronbunshu
In building a human-robot cooperative system, it is an important issue to reduce the harm caused by contact with the robot. A protective measure for a robot with a sharp and highly rigid surface is to smoothen the surface shape and reduce the rigidity in
Yusuke MORITA, Yoji YAMADA
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source