Results 51 to 60 of about 702,139 (267)
Analysis and Improvement of Pantograph Carbon Strip Abnormal Wear on Luoyang Metro Line 1
Chengshi guidao jiaotong yanjiuObjective During inspection, problems like the bad pantograph and catenary relation, pantograph-catenary arcing on the main line, burning points and serious wear on the pantograph carbon strip are detected since the trial operation of Luoyang Metro Line ...
WANG Liang, NIU Xiurong, LUO Min
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FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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Shiyou jixie, 2021 The normal operation of drilling tool is directly affected by the strength and sealing performance of its threaded joint. Therefore, in order to ensure the smooth progress of oil and gas production, it is necessary to analyze the strength and sealing ...
Liu Yonggang, Yin Chengxian, Ding Yuqi
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Influence of Casing Wear on Sealing Performance of Packer
Shiyou jixie, 2021 In the process of drilling oil and gas wells in western China, severe casing wear occurred in many ultra-deep wells; however, in some special cases, the packer had to be set in the casing wear interval.
Wang Jieli +3 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Ultrasonic Detection Method for Sealing Performance of Special Thread Tubing
Shiyou jixie, 2021 The size and distribution of contact pressure on the sealing surface of special thread tubing have an important impact on its sealing performance. In this paper, pressure was applied on the double rough surface to simulate the contact process of sealing ...
Han Ting +3 more
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source