Results 71 to 80 of about 721,658 (313)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Arc motion and gas flow in current limiting circuit breakers operating with a low contact switching velocity [PDF]
, 2002 Arc motion in low voltage (240 VAC) high current (10/sup 3/-10/sup 4/A.) current limiting-circuit breakers is dominated by arc root mobility. The mobility is influenced by the gas flow and gas composition in the contact region, but there is little ...
Weaver, P.M. +2 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
A Shakedown Limit under Hertz Contact Pressure
, 2011 In his "Contact Mechanics" book, Professor K. L. Johnson described an analytical lower bound shakedown approach to predict the shakedown load limit under repeated Hertz moving surface loads.
Shiau, Jim S., Jim S. Shiau
core +1 more source
Cold hydraulic expansion of oil well tubulars [PDF]
, 2011 Peer ...
P. Wood +7 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Contact drying of particulate pharmaceuticals: modelling and simulation [PDF]
, 2010 In order to give a concrete response to the need of predictive contact drying simulation tools in pharmaceutical industry, simulation programs for contact drying of pharmaceutical powders were developed in this thesis work.
Intelvi, Marco
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Study on the Contact Pressure Trend of Plastic Seals based on Operating Conditions and Geometric Sensitivity Analysis [PDF]
한국정밀공학회지The use of environmentally friendly, lubricant-free plastic seals in the rotating parts of robots and machines is on the rise. However, variations in seal geometry and operating conditions can influence the contact pressure between the seal and shaft ...
Hyeong Jun Shim +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source