Results 61 to 70 of about 702,139 (267)

Research on Reciprocating Sealing Performance of Hydraulic Impactor Under Stress Relaxation

Shiyou jixie, 2023
Hydraulic impactors have good application effects in hard formation drilling,but the sealing performance of reciprocating seals under high-temperature and high-pressure conditions has an important influence on the service life of them.Therefore ...
Qi Yue, Liu Gonghui, Li Jun, Zha Chunqing, Tian Yudong, Zhang Yi   +5 more
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Influence of Friction Models on the Seismic Response of Box-Girder RC Bridges with Double Concave Friction Pendulum Bearings Under Varying Deck Aspect and Mass Ratios

Buildings
Friction pendulum bearings are widely used seismic isolation devices for bridges, with their behavior governed by friction during excitation. Sliding velocity and contact pressure are among the factors that substantially affect the friction coefficient ...
Muzaffer Borekci
doaj   +1 more source

Simulation Study on Sealing Performance of Special Threaded Connector Under Vibration Conditions

Shiyou jixie, 2023
The traditional statics theory cannot effectively explain the sealing failure of special threaded connector caused by pipe string vibration.Therefore,in the paper,based on the theory of energy dissipation,considering the influence of micro contact slip ...
Yu Yang, Qu Zhan, Xu Fuyan, Cao Yinping, Dou Yihua, Liu Yu   +5 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Three-dimensional finite analysis of acetabular contact pressure and contact area during normal walking

Asian Journal of Surgery, 2017
Background: This study aims to analyze the contact areas and pressure distributions between the femoral head and mortar during normal walking using a three-dimensional finite element model (3D-FEM).
Guangye Wang, Wenjun Huang, Qi Song, Jinfeng Liang   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Refreezing of frictional meltwater behind a sliding ski

Friction
Low friction on snow has been attributed to the formation of a frictional meltwater layer for many years, yet experimental evidence for this mechanism has remained inconsistent.
Michael Hasler, Werner Jud, Joost van Putten, Werner Nachbauer   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source