Results 81 to 90 of about 2,953,458 (303)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Analysis and Improvement of Pantograph Carbon Strip Abnormal Wear on Luoyang Metro Line 1

open access: yesChengshi guidao jiaotong yanjiu
Objective During inspection, problems like the bad pantograph and catenary relation, pantograph-catenary arcing on the main line, burning points and serious wear on the pantograph carbon strip are detected since the trial operation of Luoyang Metro Line ...
WANG Liang, NIU Xiurong, LUO Min
doaj   +1 more source

Benchmarking Signorini and exponential contact laws for an industrial train brake squeal application [PDF]

open access: yes, 2012
Contact representation of structure interactions for finite element models is nowadays of great interest in the industry. Two contact modellig strategies exist in the literature, either based on a perfect contact with no interpenetration of structures at
BALMES, Etienne   +3 more
core   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Measuring wheel/rail contact stresses using ultrasound [PDF]

open access: yes, 2004
The investigation of contact area and pressure distribution in a wheel/rail contact is essential information required in fatigue and wear calculations to determine design life, regrinding requirements, and maintenance schedules.
Bjorklund, S.   +4 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Analysis on the Factors Influencing Thread Stress and Sealing Performance of Double-Shoulder Drilling Tool

open access: yesShiyou jixie, 2021
The normal operation of drilling tool is directly affected by the strength and sealing performance of its threaded joint. Therefore, in order to ensure the smooth progress of oil and gas production, it is necessary to analyze the strength and sealing ...
Liu Yonggang, Yin Chengxian, Ding Yuqi
doaj  

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein   +13 more
wiley   +1 more source

Influence of Casing Wear on Sealing Performance of Packer

open access: yesShiyou jixie, 2021
In the process of drilling oil and gas wells in western China, severe casing wear occurred in many ultra-deep wells; however, in some special cases, the packer had to be set in the casing wear interval.
Wang Jieli   +3 more
doaj  

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