Results 81 to 90 of about 721,658 (313)

Analysis and Improvement of Pantograph Carbon Strip Abnormal Wear on Luoyang Metro Line 1

Chengshi guidao jiaotong yanjiu
Objective During inspection, problems like the bad pantograph and catenary relation, pantograph-catenary arcing on the main line, burning points and serious wear on the pantograph carbon strip are detected since the trial operation of Luoyang Metro Line ...
WANG Liang, NIU Xiurong, LUO Min
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Evidence on scleral contact lenses and intraocular pressure

, 2017
It has been hypothesised that scleral contact lens wear may potentially elevate intraocular pressure (IOP) as a result of post-lens fluid forces exacerbated by eyelid tension, or ocular versions that alter the lens fit and result in corneal bearing or ...
Vincent, Stephen J., Alonso-Caneiro, David, Vincent, Stephen J, Collins, Michael J, Collins, Michael J.   +4 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Contact Pressure and Flexibility of Multipin Dry EEG Electrodes

, 2018
In state-of-the-art electroencephalography (EEG) Silver/Silver-Chloride electrodes are applied together with electrolyte gels or pastes. Their application requires extensive preparation, trained medical staff and limits measurement time and mobility.
Vaz, F., Griebel, Stefan, Jens Haueisen, Frank Zanow, Stefan Griebel, Patrique Fiedler, Fonseca, Carlos, Zanow, Frank, Fiedler, Patrique, Pedrosa, Paulo Eduardo Teixeira Baptista, Carlos Fonseca, Filipe Vaz, Paulo Pedrosa, Muehle, Richard, Haueisen, Jens, Richard Muhle   +15 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Analytical formulation of the contact pressure evolution for interference joints under creep regime

, 2020
An analytical formulation to evaluate the contact pressure evolution in interference fit joints working under high temperature regime, is proposed. The phenomenon is mainly due to the stress relaxation related to the creep behaviour of materials used to ...
Esposito L., Bertocco A., Bruno M.
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Ultrasonic Reflection for Measurement of Oil Film Thickness and Contact between Dissimilar Materials [PDF]

, 2012
The contact between dissimilar materials occurs in many machine elements where one of the contacting parts is manufactured from low modulus materials such as lip seals, o-rings, and metal on polymer prosthetic hip joints.
Gasni, Dedison
core