Results 61 to 70 of about 3,517,154 (297)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Fatigue analysis of catenary contact wires for high speed trains [PDF]
, 2011 The fatigue fracture is one of the most critical failures which may occur on the high speed network because it is undetectable and it has a huge impact on traffic disruption.
MAITOURNAM, Habibou +4 more
core
Transmission of Hemagglutinin D222G Mutant Strain of Pandemic (H1N1) 2009 Virus
Emerging Infectious Diseases, 2010 A pandemic (H1N1) 2009 virus strain carrying the D222G mutation was identified in a severely ill man and was transmitted to a household contact. Only mild illness developed in the contact, despite his obesity and diabetes.
Simona Puzelli +10 more
doaj +1 more source
Experimental study on shear mechanical properties of soil-rock mixture-bedrock interface
Yantu gongcheng xuebao, 2020 The shear strength of the interface between the fill and the underlying bedrock is an important factor to control the stability of high fill or accumulation slopes.
YANG Zhong-ping 1, 2, 3, JIANG Yuan-wen 1, 2, 3, LI Shi-qi 1, 2, 3, LI Jin 1, 2, 3, HU Yuan-xin 4
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Improving the contact resistance at low force using gold coated carbon nanotube surfaces [PDF]
, 2010 Investigations to determine the electrical contact performance under repeated cycles at low force conditions for carbon-nanotube (CNT) coated surfaces were performed. The surfaces under investigation consisted of multi-walled CNT synthesized on a silicon
S. M. Spearing +8 more
core +1 more source
SensorsThis manuscript proposes a non-contact approach to characterize geometrical configuration and strain rate effects using digital image correlation (DIC).
Cheng Chen, Liuyang Feng
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source