Results 61 to 70 of about 589,209 (313)

Casting a wide net: use of diverse model organisms to advance toxicology [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hahn, M. E., & Sadler, K. C. Casting a wide net: use of diverse model organisms to advance toxicology.
Hahn, Mark E., Sadler, Kirsten C.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Target product profiles for protecting against outdoor malaria transmission. [PDF]

, 2012
BACKGROUND\ud \ud Long-lasting insecticidal nets (LLINs) and indoor residual sprays (IRS) have decimated malaria transmission by killing indoor-feeding mosquitoes.
BD Foy, C Garrett-Jones, D Strickman, DW Meyrowitsch, EW Kimani, FG Cobelens, FO Okumu, Gerry F Killeen, GF Killeen, GF Killeen, H Bugoro, H Kawada, H Pates, HV Pates, JP Grieco, JT Griffin, K Macintyre, L Yakob, M Reddy, M Sylla, MN Bayoh, MT Gillies, MT Gillies, MT Gillies, MT Gillies, NJ Govella, PL Jones, R Elliott, RC Muirhead-Thomson, RL Kouznetsov, Sarah J Moore, SL Turner, TL Russell, TL Russell, WA Hawley, WHO, WHO   +36 more
core   +6 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Chemical Composition and Insecticidal Activity Against <em>Sitophilus zeamais</em> of the Essential Oils Derived from <em>Artemisia giraldii</em> and <em>Artemisia subdigitata</em>

Molecules, 2012
The aim of this research was to determine the chemical composition and insecticidal activity of the essential oils derived from flowering aerial parts of <em>Artemisia giraldii </em>Pamp. and <em>A. subdigitata</em> Mattf. (Family:
Zhi-Long Liu, Shu-Shan Du, Zhi-Wei Deng, Sha-Sha Chu   +3 more
doaj   +1 more source

Chemical constituents and biological activities against Tribolium castaneum (Herbst) of the essential oil from Citrus wilsonii leaves [PDF]

Journal of the Serbian Chemical Society, 2014
The essential oil obtained from Citrus wilsonii Tanaka leaves with hydrodistillation was investigated by GC and GC-MS. The main components of the essential oil were identified to be citronellol (16.94%), nerol acetate (10.35%), γ-terpinen (9.85%)
Chen Hai Ping, Yang Kai, You Chun Xue, Du Shu Shan, Cai Qian, He Qing, Geng Zhu Feng, Deng Zhi Wei   +7 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

CO2 whole area irradiative processing and patterning of nylon 6,6 and the effects thereof on osteoblast cell response in relation to wettability [PDF]

, 2010
CO2 laser processing of nylon 6,6 can modify its wettability and biomimetic characteristics. This paper discusses comparatively the use of a CO2 laser for surface patterning and whole area processing, detailing the effects on the wettability and ...
Lawrence, Jonathan, Waugh, David
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The use of essential oils for the control of Callosobruchus subinnotatus (Pic) in stored Vigna subterranea L.

Julius-Kühn-Archiv, 2018
Studies were conducted in the Crop Science laboratory, University of Calabar to evaluate the insecticidal actions of essential oils (EOs) of Xylopia aethiopica, Dennetia tripetala, Pysostigma venenosum and Senna hirsuta in the management of ...
Umoetok, Sylvia Bassey, Archibong, Boniface Effiong, Okweche, Simon Idoko   +2 more
doaj   +1 more source