Results 51 to 60 of about 480,834 (326)

Leprosy New Case Detection Trends and the Future Effect of Preventive Interventions in Pará State, Brazil: A Modelling Study [PDF]

open access: yes, 2016
Background: Leprosy remains a public health problem in Brazil. Although the overall number of new cases is declining, there are still areas with a high disease burden, such as Pará State in the north of the country. We aim to predict future trends in new
Blok, D.J. (David)   +3 more
core   +6 more sources

How is “solidarity” understood in discussions about contact tracing apps? An overview

open access: yesFrontiers in Public Health, 2022
BackgroundIn the context of the COVID-19 pandemic, there is much discussion about contact tracing apps, their use to contain the spread of the virus as well as the ethical, legal, and social aspects of their development, implementation, acceptance, and ...
Max Tretter
doaj   +1 more source

Contact tracing and epidemics control in social networks

open access: yes, 2002
A generalization of the standard susceptible-infectious-removed (SIR) stochastic model for epidemics in sparse random networks is introduced which incorporates contact tracing in addition to random screening.
A. Johansen   +13 more
core   +1 more source

Evaluation of a Contact Tracing Training Program and Field Experience

open access: yesAJPM Focus, 2022
Introduction: The study objective was to evaluate a contact tracing training program and the role of contact tracing on volunteers’ professional development.
Katherine M. Strelau, BS   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Resident Willingness to Participate in Digital Contact Tracing in a COVID-19 Hotspot: Findings From a Detroit Panel Study

open access: yesJMIR Public Health and Surveillance, 2023
BackgroundDigital surveillance tools and health informatics show promise in counteracting diseases but have limited uptake. A notable illustration of the limits of such tools is the general failure of digital contact tracing in ...
Lydia Wileden   +3 more
doaj   +1 more source

Contact tracing and disease control [PDF]

open access: yesProceedings of the Royal Society of London. Series B: Biological Sciences, 2003
Contact tracing, followed by treatment or isolation, is a key control measure in the battle against infectious diseases. It is an extreme form of locally targeted control, and as such has the potential to be highly efficient when dealing with low numbers of cases.
Ken T D, Eames, Matt J, Keeling
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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