Results 81 to 90 of about 45,740 (299)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

EFFICIENCY ANALYSIS OF COBB-DOUGLAS PRODUCTION FUNCTION IN KOJA CONTAINER TERMINAL, TANJUNG PRIOK PORT [PDF]

open access: yes, 2015
Container terminal efficiency and productivity is important issues since productivity of container terminal in Indonesia is the low but the total handling charge is relatively high compared in ASEAN.
MAHARANI, Maharani, SUSILOWATI, Indah
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A Study on the Efficiency of Container Terminals in Korea and China

open access: yesAsian Journal of Shipping and Logistics, 2016
The objective of this study is to derive implications required for efficiency improvement and management level enhancement by selecting container terminals within major large ports of Korea and China as comparison units, evaluating their relative ...
Xue Bin Zheng, Nam Kyu Park
doaj   +1 more source

A Multi-Heuristic Approach for Solving the Pre-Marshalling Problem

open access: yes, 2014
Minimizing the number of reshuffling operations at maritime container terminals incorporates the Pre-Marshalling Problem (PMP) as an important problem.
Jovanovic, Raka   +2 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Method and apparatus for detection and location of microleaks Patent [PDF]

open access: yes, 1967
Microleak detector mounted on weld seam of propellant tank of launch ...
Mitchell, N. M.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Systems Biology Graphical Notation: Activity Flow language Level 1 [PDF]

open access: yes, 2009
Standard graphical representations have played a crucial role in science and engineering throughout the last century. Without electrical symbolism, it is very likely that our industrial society would not have evolved at the same pace.
Anatoly Sorokin   +4 more
core   +2 more sources

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