Results 81 to 90 of about 45,682 (299)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Brazilian Journal of Operations & Production Management, 2016 Purpose: Due to the competitiveness required in this port sector, analyzes the efficiency of the operations become relevant. Therefore, the main goal of this paper is to assess the technical efficiency of the operations in Brazilian public container ...
Ilton Curty Leal Junior +3 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
A Study on the Efficiency of Container Terminals in Korea and China
Asian Journal of Shipping and Logistics, 2016 The objective of this study is to derive implications required for efficiency improvement and management level enhancement by selecting container terminals within major large ports of Korea and China as comparison units, evaluating their relative ...
Xue Bin Zheng, Nam Kyu Park
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Global Trade Impacts: Addressing the Health, Social and Environmental Consequences of Moving International Freight Through Our Communities [PDF]
, 2011 Examines freight transportation industry trends; the impact of global trade on workers, the environment, and health in both exporting and importing countries; and organizing strategies and policy innovations for minimizing the damage and ensuring ...
Andrea Hricko +3 more
core
Containerisation in the Baltic Sea region: development, characteristics and contemporary organisation [PDF]
, 2019 The main focus of the paper is on the container system development in the Baltic Sea Region studying cotemporary changes and organisation, as well as explaining the main driving forces of this situation.
Serry, Arnaud
core +4 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Method and apparatus for detection and location of microleaks Patent [PDF]
, 1967 Microleak detector mounted on weld seam of propellant tank of launch ...
Mitchell, N. M.
core +1 more source