Results 71 to 80 of about 387,798 (268)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Assessment of Arsenic and Lead in Urban Park Soils in Newark, New Jersey, USA

Soil Systems
Soils in seven urban parks in Newark, New Jersey (NJ), United States, were evaluated for arsenic (As) and lead (Pb) by field and laboratory methods. Surface (S1, 0–3 cm) and near-surface (S2, 4–7 cm) soils in high-contact areas of the parks were analyzed
Suah Yekeh, Ashaki A. Rouff
doaj   +1 more source

Evaluation of temporary seasonal variation of heavy metals and their potential ecological risk in Nzhelele River, South Africa

Open Chemistry, 2017
Surface water is often used as alternative source of drinking water in many regions of the world where the potable water supply is erratic or not present. The concentration of heavy metals was assessed using an Inductively Coupled Plasma Optical Emission
Edokpayi Joshua N., Odiyo John O., Popoola Elizabeth O., Msagati Titus A.M.   +3 more
doaj   +1 more source

Comparison of Workplace Protection Factors for Different Biological Contaminants

Journal of Occupational and Environmental Hygiene, 2011
This study compared workplace protection factors (WPFs) for five different contaminants (endotoxin, fungal spores, (1→3)-β-D-glucan, total particle mass, and total particle number) provided by an N95 elastomeric respirator (ER) and an N95 filtering facepiece respirator (FFR). We previously reported size-selective WPFs for total particle numbers for the
Cho, Kyungmin Jacob, Reponen, Tiina, McKay, Roy, Dwivedi, Alok, Adhikari, Atin, Singh, Umesh, Shukla, Rakesh, Jones, M. Susan, Jones, Gordon, Grinshpun, Sergey A.   +9 more
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Geochemical Factors as a Tool for Distinguishing Geogenic from Anthropogenic Sources of Potentially Toxic Elements in the Soil

Land
Potentially toxic element (PTE) contamination of soils and their sources remains one of key global environmental concerns. Agricultural soil in Kalinovac, Podravina region, Croatia is the subject of this study.
Tomislav Brenko, Stanko Ružičić, Niko Radonić, Martina Puljko, Marko Cvetković   +4 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

ANALYSIS OF SEASONAL VARIATION ON DEGREE OF CONTAMINATION WITH HEAVY METALS IN AARJATE VILLAGE, MOROCCO. AN INDEX APPROACH

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2015
Water samples from wells and samples from soil nearby them were taken during dry (June-September 2013) and wet (December 2013, January - February 2014) seasons and concentrations of Cd, Cu, Mn, Ni, Pb and Zn were determined. Contamination Factor for each
FRANÇOIS X. NSHIMIYIMANA, MARIA-EMA FACIU, ABDELLAH EL ABIDI, SOUAD EL BLIDI, MOHAMED FEKHAOUI, IRINA LOREDANA IFRIM, ABDELMAJID SOULAYMANI, GABRIEL LAZAR   +7 more
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source