Results 51 to 60 of about 1,781 (263)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Evidence in Favor of Homoparental Adoption: Analysis of Parenting Styles [PDF]

open access: yesPsicologia: Teoria e Pesquisa
This study analyzed the parenting styles of 64 adoptive couples, 13 heteroaffective, and 19 homoaffective. We used the Parenting Styles Inventory to assess parenting styles.
Paula Inez Cunha Gomide   +2 more
doaj   +4 more sources

Early‐Phase Research in Pediatric Neuro‐Oncology

open access: yes
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Foreword 前言

open access: yesContemporaneity: Historical Presence in Visual Culture, 2015
An introduction to the Open Ground Blog interviews included in this issue of Contemporaneity.  
Gao Minglu
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Sobre juventude e leitura na "idade mídia": implicações para políticas e práticas curriculares On youth and reading in Age Media: implications for curricular policies and practices

open access: yesEducar em Revista, 2013
Com base em pesquisa institucional, interessada em investigar as relações entre leitura, escrita e mídia, focalizamos neste texto a experiência contemporânea de leitura de jovens estudantes do Ensino Médio de escolas públicas e particulares do Estado do ...
Maria Luiza Oswald   +1 more
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

ESTADO E CULTURA NA CONTEMPORANEIDADE: Portugal e Brasil em foco

open access: yesRevista de Políticas Públicas, 2007
Outline of analytical elements about the Contemporaneous State according to its insertion in a money-oriented civilization where the focus goes to the study of the relation State/Culture, having as empirical reference the European scenario, highlighting ...
Maria Manuel Baptista   +3 more
doaj  

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