Results 71 to 80 of about 27,052,763 (294)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Content-based colour image filters

Electronics Letters, 1997
A nonlinear ranked-order filter based on a content model of similarity is proposed for colour image processing. Simulation results indicate that the new filter suppresses impulsive as well as Gaussian noise and preserves edges and details.
K.N. Plataniotis, D. Androutsos, A.N. Venetsanopoulos   +2 more
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Pekalongan Regency Tourism Recommendation System with Content based Filtering

Sistemasi: Jurnal Sistem Informasi
This study implements content-based filtering for a tourist recommendation system in Pekalongan Regency. The method utilizes the TF-IDF algorithm to measure the weight of tourist attraction categories and cosine similarity to assess the similarity ...
Cinta Salsabilla, Danang Wahyu Utomo
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Movie Recommendation System Using Content Based Filtering

Al-Bāhir, 2023
Sribhashyam Rakesh
doaj   +1 more source

ANALYSIS OF CONTENT RECOMMENDATION METHODS IN INFORMATION SERVICES

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
The object of the research is the process of selecting a content recommendation method in information services. The study's relevance stems from the rapid development of informational and entertainment resources and the increasing volume of data they ...
Oleksandr Necheporuk, Svitlana Vashchenko, Nataliia Fedotova, Iryna Baranova, Yaroslava Dehtiarenko   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Hybrid-Based Movie Recommender System: Techniques, Case Studies, Evaluation Metrics, and Future Trends

Journal of Informatics and Web Engineering
The necessity for sophisticated recommender systems in the movie recommendation sphere has become particularly pronounced, generating a more personalized movie recommendation due to people nowadays who like to watch movies online.
Cheng-Yung Lai, Noramiza Hashim, Lucia Dwi Krisnawati   +2 more
doaj   +3 more sources