Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Enhancing Port Performance through Digital Transformation: The Role of Networking Capability and Organizational transformation in Indonesian Container Ports. [PDF]
Pramitra B +3 more
europepmc +1 more source
Researches on Optimized Caching and Forwarding of Content-Centric Networking [PDF]
Chengming Li
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Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Hash-Based Cache Distribution and Search Schemes in Content-Centric Networking
Yurino Sato, Yusuke Ito, Hiroyuki Koga
openalex +2 more sources
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Evaluation of the Positive Peers Mobile App for Supporting the Viral Suppression of Young People With HIV: Protocol for a Concurrent Mixed Methods Evaluation With Randomized Controlled Clinical Trial and Observational Cohort. [PDF]
Step MM +8 more
europepmc +1 more source
KRB-CCN: Lightweight Authentication & Access Control for Private Content-Centric Networks [PDF]
Ivan O. Nunes, Gene Tsudik
openalex
A Mobility-Aware Vehicular Caching Scheme in Content Centric Networks: Model and Optimization [PDF]
Yao Zhang +5 more
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