Results 131 to 140 of about 10,690,579 (262)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Development and Content Validation of an Exercise-Based Framework for the Management of Lumbar Radiculopathy. [PDF]

Physiother Res Int
Naidu SP, Suresh A, Haridass S, Harikesavan K.   +3 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Study of Human Papillomavirus Vaccine-Related Social Media Content Across Eight Social Media Platforms: Scoping Review of Communication Content, Information Sources, and Analytical Approaches. [PDF]

J Med Internet Res
Xu Y, Cong R, Liu M, Zhou S, Sakaguchi M, Katayama K, Jin Q, Nishimura S, Ogihara A.   +8 more
europepmc   +1 more source

Accademischer Frauenzimmer-Spiegel, Das ist Einige curieuse Liebes-Begebenheiten, So sich in der That auf einer wohlbekandten Sächsischen Universität vor einigen Jahren zugetragen / Ausgefertigt von Le Content

Le Content ist ein PseudonymAutopsie nach dem Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Jm Jahr 1718.Frontispiz (Kupferst.
Le Content
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The Association of Apparent Myelin Water Fraction With Diffusional Kurtosis and Biophysical Modeling Parameters. [PDF]

NMR Biomed
Moss HG, Sugarman MA, Lee J, Chen AA, Jensen JH, Benitez A.   +5 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The impact of appearance-focussed social media and self-objectification on mood. [PDF]

PLoS One
Jones SM, Pasternak FA, Heerey EA.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source