Results 71 to 80 of about 4,466,597 (305)

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System

open access: yesCells, 2020
The blood-brain barrier (BBB) is responsible for the homeostasis between the cerebral vasculature and the brain and it has a key role in regulating the influx and efflux of substances, in healthy and diseased states.
Annalise Di Marco   +16 more
doaj   +1 more source

Co-evolution of Content Popularity and Delivery in Mobile P2P Networks [PDF]

open access: yesarXiv, 2011
Mobile P2P technology provides a scalable approach to content delivery to a large number of users on their mobile devices. In this work, we study the dissemination of a \emph{single} content (e.g., an item of news, a song or a video clip) among a population of mobile nodes.
arxiv  

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Secure Fragmentation for Content-Centric Networks (extended version) [PDF]

open access: yesarXiv, 2014
Content-Centric Networking (CCN) is a communication paradigm that emphasizes content distribution. Named-Data Networking (NDN) is an instantiation of CCN, a candidate Future Internet Architecture. NDN supports human-readable content naming and router-based content caching which lends itself to efficient, secure, and scalable content distribution ...
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Content-Priority based Interest Forwarding in Content Centric Networks [PDF]

open access: yesarXiv, 2014
Content Centric Networking (CCN) is a recent advancement in communication networks where the current research is mainly focusing on routing & cache management strategies of CCN. Nonetheless, other perspectives such as network level security and service quality are also of prime importance; areas which have not been covered deeply so far.
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

TRAINING TECHNOLOGIES IN THE EDUCATION OF LYCEUM STUDENTS (ON THE EXAMPLE OF LYCEUMS OF SECURITY AND NATIONAL PATRIOTIC EDUCATION OF THE MINISTRY OF INTERNAL AFFAIRS OF UKRAINE)

open access: yesНеперервна професійна освіта: теорія та практика
The article highlights the specifics of the activities of security-oriented lyceums and national-patriotic education within the Ministry of Internal Affairs of Ukraine.
Ievgen Bazhenkov   +2 more
doaj   +1 more source

Influence of Selective Exposure to Viewing Contents Diversity [PDF]

open access: yesarXiv, 2018
Personalization, including both self-selected and pre-selected, is inevitable when tremendous amounts of media content are available. Personalization, which is believed to cause people to consume fewer diverse contents, can lead to fragmentation and polarization in society.
arxiv  

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