Results 101 to 110 of about 1,230,989 (267)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

ADIR: Advanced domain‐invariant representation via decoupling learning and information bottleneck

IET Image Processing
The discrepancy in data distribution between training and testing scenarios, as well as the inductive bias of convolutional neural networks towards image styles, reduces the model's generalization ability.
Yangyang Zhong, Yunfeng Yan, Pengxin Luo, Yuhao Zhou, Donglian Qi   +4 more
doaj   +1 more source

Non-Destructive Characterization of Drywall Moisture Content Using Terahertz Time-Domain Spectroscopy

Sensors
Despite its wide acceptance, one of the most critical limitations of Terahertz wave technology is its high sensitivity to moisture. This limitation can, in turn, be exploited for use in moisture detection applications.
Habeeb Foluso Adeagbo, Binbin Yang
doaj   +1 more source

Subject Analysis, Content Analysis and Domain Analysis

The Canadian Journal of Information and Library Science
From the perspective of the constant increase in data and information, consider in Library and Information Science that the correct analysis and representation of the contents of documents analyzed in specific domains is essential for the retrieval, organization, and dissemination of information.
Alves Silva Portella, Tauany Lorena, de Lima, Gercina Ângela   +1 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Cognitive Linguistic Study on Arabic Female BA Students’ Perceptions of Their Teachers in an English Department

Nalans
The contemporary age has witnessed many challenges regarding the common and conventional qualities of the best teacher. Langacker’s traditional model of Domain Analysis (1987), that is, the matrix domains of content, design, and delivery, still provides ...
Rana H. Al-Bahrani, Hutheifa Yousif Turki, Imad Hayif Sameer   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Translation, reliability, and validation of the Dutch Safe Use of Mobility Aid Checklist (SUMAC-NL) for walker use in people living with dementia [version 3; peer review: 2 approved]

F1000Research
Background People with dementia have a yearly risk of falling of 60 to 80 percent. Therefore, a walker is often recommended. However, the use of a walker in people with dementia is associated with a threefold increased odds of falls compared to their ...
Susan Hunter, Hans Drenth, Jesper Kroesen, Hans Hobbelen, Helen Bruinsma   +4 more
doaj   +1 more source