Results 81 to 90 of about 1,230,989 (267)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
TVDR: A Two-Level Virtual Domain Routing Scheme for Content-Centric Networking
IEEE Access, 2018 In content-centric networking (CCN), the content is retrieved based on its name with the aid of in-network caching, instead of relying on IP address. Since the number of content names is several orders of magnitude higher than that of IP addresses, it ...
Jie Li, Xingwei Wang, Min Huang
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The effect of sediment content to fluid - solid interface time-domain waveform
MATEC Web of Conferences, 2016 A model was established for the fluid - solid interface of semi-infinite medium, and the characteristic equation was established using the potential function.
Qi Li Hua +5 more
doaj +1 more source
An Intelligent Content Discovery Technique for Health Portal Content Management
JMIR Medical Informatics, 2014 BackgroundContinuous content management of health information portals is a feature vital for its sustainability and widespread acceptance. Knowledge and experience of a domain expert is essential for content management in the health domain.
De Silva, Daswin, Burstein, Frada
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Frontiers in PsychologyIntroductionWorked examples support initial skill acquisition. They often show skill application on content knowledge from another, “exemplifying” domain (e.g., argumentation skills have to be applied to some contents).
Nina Udvardi-Lakos +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Domain and Content Adaptive Convolutions for Cross-Domain Adenocarcinoma Segmentation
Recent advances in computer-aided diagnosis for histopathology have been largely driven by the use of deep learning models for automated image analysis. While these networks can perform on par with medical experts, their performance can be impeded by out-of-distribution data.
Wilm, Frauke +3 more
openaire +2 more sources