Results 51 to 60 of about 261,477 (240)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The impact of advanced rapeseed pretreatment technology on minor compounds in rapeseed oil: A review

Oil Crop Science
Rapeseed is the primary domestic source of edible vegetable oil in China. Its oil is naturally rich in phytosterols, polyphenols, tocopherols, carotenoids and other lipid-soluble companions, which are highly beneficial to human health.
Dan Wang, Jinghan Miao, Hua Zhang, Hong Chen, Fang Wei   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Material basis differences and production process consistency rapid screening of health food raw material Aloe vera

Shipin yu jixie
ObjectiveTo explore the effects of different production processes on the material basis of Aloe vera as a health food raw material, and to establish a rapid screening method for assessing production process consistency.MethodsPlant metabolomics ...
ZHAO Zirui, SA Yi, ZHAO Chan, ZHOU Xiaojuan, ZHANG Mengling   +4 more
doaj   +1 more source

Classification of 3D Archaeological Objects Using Multi-View Curvature Structure Signatures

IEEE Access, 2019
We propose a generalized 3D shape descriptor for the efficient classification of 3D archaeological artifacts. Our descriptor is based on a multi-view approach of curvature features, consisting of the following steps: pose normalization of 3D models ...
Mario Canul-Ku, Rogelio Hasimoto-Beltran, Diego Jimenez-Badillo, Salvador Ruiz-Correa, Edgar Roman-Rangel   +4 more
doaj   +1 more source

Reviewer Integration and Performance Measurement for Malware Detection

, 2016
We present and evaluate a large-scale malware detection system integrating machine learning with expert reviewers, treating reviewers as a limited labeling resource.
Afroz, Sadia, Bachwani, Rekha, Faizullabhoy, Riyaz, Huang, Ling, Joseph, Anthony D., Kantchelian, Alex, Miller, Brad, Shankar, Vaishaal, Tschantz, Michael Carl, Tygar, J. D., Wu, Tony, Yiu, George   +11 more
core   +1 more source