Results 81 to 90 of about 2,282,359 (291)

A reexamination of information theory-based methods for DNA-binding site identification

BMC Bioinformatics, 2009
Background Searching for transcription factor binding sites in genome sequences is still an open problem in bioinformatics. Despite substantial progress, search methods based on information theory remain a standard in the field, even though the full ...
O'Neill Michael C, Erill Ivan
doaj   +1 more source

Quantum Probability as an Application of Data Compression Principles [PDF]

Electronic Proceedings in Theoretical Computer Science, 2016
Realist, no-collapse interpretations of quantum mechanics, such as Everett's, face the probability problem: how to justify the norm-squared (Born) rule from the wavefunction alone.
Allan F. Randall
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Approximation of length minimization problems among compact connected sets [PDF]

, 2014
In this paper we provide an approximation \`a la Ambrosio-Tortorelli of some classical minimization problems involving the length of an unknown one-dimensional set, with an additional connectedness constraint, in dimension two. We introduce a term of new
Bonnivard, Matthieu, Lemenant, Antoine, Santambrogio, Filippo   +2 more
core   +2 more sources

Four-dimensional lattice chiral gauge theories with anomalous fermion content

, 2007
In continuum field theory, it has been discussed that chiral gauge theories with Weyl fermions in anomalous gauge representations (anomalous gauge theories) can consistently be quantized, provided that some of gauge bosons are permitted to acquire mass ...
D. Kadoh, D. Kadoh, D. Kadoh, Hiroshi Suzuki, K. Matsui, N.V. Krasnikov, S. Chandrasekharan, T. Fujiwara, Y. Kikukawa, Yoshio Kikukawa   +9 more
core   +1 more source

Information content of colored motifs in complex networks [PDF]

, 2011
We study complex networks in which the nodes of the network are tagged with different colors depending on the functionality of the nodes (colored graphs), using information theory applied to the distribution of motifs in such networks.
Arend Hintze, Christoph Adami, Jifeng Qian, Kolmogorov A., Matthew Rupp   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source