Results 101 to 110 of about 562,796 (312)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Content Validity of Instruments in IS Research [PDF]
, 2006 This paper presents a literature review of content validity, summarizes qualitative and quantitative approaches for content validity assessment, and explores the extent to which IS researchers have content validated their developed instruments.
Tojib, Dewi Rooslani, Sugianto, Ly-Fie
core +1 more source
Development and Content Validation of a Novel Iliotibial Band Friction Syndrome Index Questionnaire: A Cross-sectional Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: The Iliotibial Band Friction Syndrome (ITBFS) diagnosis is based on clinical reasoning. Ober’s test and the Noble compression test are examples of diagnostic techniques, but there is no specific diagnostic standard assessment questionnaire ...
Ritika Kashyap +5 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Measuring content validity , face validity and ecological-digital validity [PDF]
Background: Many observational instruments have been developed to measure aspects of the parent-child relationship or interaction patterns. However, given the flood of terms and scale labels, these instruments often suffer from a lack of factorial ...
Müller, Jörg Michael
core +1 more source
Item and Scale Content Validity Indexes. [PDF]
, 2016 Item and Scale Content Validity Indexes.
Leanne Chalmers (564165) +2 more
core +1 more source
International Journal of Communication, 2021 For the last decade, research has shown inconsistent findings about validity of parental mediation scales for children’s Internet use. This inconsistency has manifested itself in at least 10 parental mediation models, which are also inconsistent in ...
Seffetullah Kuldas +3 more
doaj